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首页> 外文学位 >Analytical and bioassay studies of North American hop (Humulus lupulus L.) varieties and hop products for the potent phytoestrogen 8-prenylnaringenin.
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Analytical and bioassay studies of North American hop (Humulus lupulus L.) varieties and hop products for the potent phytoestrogen 8-prenylnaringenin.

机译：北美蛇麻草（Humulus lupulus L.）品种和蛇麻草产品的有效植物雌激素8-异戊烯基柚皮素的分析和生物分析研究。

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摘要

Produced by plants, phytoestrogens are chemicals that have the ability to mimic biological effects of the female hormone estrogen. Due to the possible health effects of their consumption, these compounds have received a great deal of attention lately. Epidemiological studies supported by laboratory findings suggest that phytoestrogens may be linked to low incidence of hormone related cancers as well as menopausal symptoms, osteoporosis and cardiovascular diseases. On the other hand, the adverse effects on fertility and reproductive development observed in wild, domestic and experimental animals have raised a concern about possibility of such effects in humans.; 8-prenylnaringenin, a potent phytoestrogen present in hops and beer, exhibits an estrogenic activity greater than that of any other known phytoestrogen. In the present study, a simple, rapid and reproducible method has been developed for determination of 8-prenylnaringenin in hops and hop products. Linearity of the method was shown to be excellent, with R2 > 0.999. Recoveries were between 95.0% (0.25 μg/mL) and 105.9% (1.0 μg/mL).; The method was used for quantitation of 8-prenylnaringenin in 24 American hop varieties. Some of the varieties were in different product forms, and harvested in two different years. The levels were shown to vary among hop varieties and hop products. Dried cones and hop pellets contained approximately the same amount of 8-prenylnaringenin, while carbon dioxide extracts of hops did not contain any. Hops spent during the production of carbon dioxide extracts, on the other hand, were shown to be rich source of 8-prenylnaringenin and could be used for its isolation. The concentration of 8-prenylnaringenin in hops varied with harvest year. Estrogenic activity of hops was assessed by growth based and β-galactosidase assays. The activity varied among hop varieties in the same fashion as the concentration of 8-prenylnaringenin. In the growth based assay, 8-prenylnaringenin showed the same affinity for α and β estrogen receptors.
机译：植物雌激素是植物产生的化学物质，具有模仿女性荷尔蒙雌激素的生物学作用的能力。由于它们的食用可能对健康产生影响，这些化合物最近受到了广泛的关注。实验室研究结果支持的流行病学研究表明，植物雌激素可能与激素相关癌症，更年期症状，骨质疏松和心血管疾病的发生率低有关。另一方面，在野生，家养和实验动物中观察到的对生育力和生殖发育的不利影响引起了人们对这种影响的担忧。啤酒花和啤酒中存在的有效植物雌激素8-异戊烯基柚皮素的雌激素活性高于任何其他已知的植物雌激素。在本研究中，已开发出一种简单，快速且可重现的方法来测定啤酒花和啤酒花产品中的8-异戊烯基柚皮素。结果表明，该方法具有良好的线性，R 2

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  • 作者

    Eri, Sanja.;

  • 作者单位

    Rutgers The State University of New Jersey - New Brunswick.;

  • 授予单位 Rutgers The State University of New Jersey - New Brunswick.;
  • 学科 Agriculture Food Science and Technology.
  • 学位 Ph.D.
  • 年度 2001
  • 页码 73 p.
  • 总页数 73
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 农产品收获、加工及贮藏;
  • 关键词

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