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首页> 外文学位 >Tumor necrosis factor-alpha, transforming growth factor-beta1, and insulin-like growth factor-I mRNA levels in the skeletal muscle of Hispanic elders with type 2 diabetes: Effects of strength training.
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Tumor necrosis factor-alpha, transforming growth factor-beta1, and insulin-like growth factor-I mRNA levels in the skeletal muscle of Hispanic elders with type 2 diabetes: Effects of strength training.

机译：2型糖尿病西班牙裔老年人骨骼肌中的肿瘤坏死因子-α，转化生长因子-β1和胰岛素样生长因子-I mRNA水平：力量训练的效果。

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摘要

The purpose of this study was to determine whether differences exist in the levels of tumor necrosis factor-α (TNF-α), transforming growth factor-β1 (TGF-β1), and insulin-like growth factor-I (IGF-I) mRNAs in skeletal muscle, and/or circulating levels of TNF-α between Hispanic diabetic and non-diabetic elders. Thirty moderately obese men (n = 15) and women (n = 15) aged 67.0 ± 7.3 years, with type 2 diabetes, and 9 moderately obese non-diabetic men (n = 4) and women (n = 5), aged 60 ± 4 years were studied. An additional purpose was to study the effects of strength training (ST) on the mRNA levels of these factors in muscle. Diabetic subjects were randomized into two groups. The training (EX) group, (8 women, 7 men) participated in 16 weeks of ST, and the control (CON) group (7 women, 8 men) maintained their usual diabetic care only. Non-diabetic subjects served as a baseline comparison group. There were no differences in weight, waist hip ratio or plasma TNF-α levels between diabetic and non-diabetic subjects. Diabetic subjects had higher plasma TNF soluble receptor (sTNFRII) levels (P 0.001), and higher muscle TNF-α (P 0.01), TGF-β1 (P 0.01) and IGF-I (P 0.05) mRNA levels, than non-diabetics. ST resulted in a reduction in % HbA1c (P 0.01), a decrease in fasting plasma insulin (P 0.05), and increases in fat free mass (P 0.005) and strength (P 0.001). Also, ST resulted in an increase in TNF-α mRNA expression (P 0.05) that was significantly correlated (r = 0.86, P 0.001) with a ST-induced increase in TGF-β1 mRNA (P 0.05). This increase in TGF-β1 mRNA was correlated (r = 0.74, P 0.001) with a 2-fold increase (P 0.001) in IGF-1 mRNA. All changes, except for fasting insulin and TNF-α mRNA, were significant when compared to the CON group (P 0.05). There were no changes in fasting glucose, plasma TNF-α or sTNFRII in either group. Thus, as an adjunct of diabetic care, ST results in improved glycemic control in Hispanic elders with type 2 diabetes, despite lack of change in circulating TNF-α, and an elevation in muscle TNF-α mRNA levels.
机译：这项研究的目的是确定肿瘤坏死因子-α（TNF-α），转化生长因子-β1（TGF-β1）和胰岛素样生长因子-I（IGF-I）的水平是否存在差异。西班牙裔糖尿病和非糖尿病老年人的骨骼肌mRNA和/或TNF-α循环水平。 30名67.0±7.3岁的中度肥胖男性（n = 15）和女性（n = 15），患有2型糖尿病，以及9名中度肥胖的非糖尿病男性（n = 4）和女性（n = 5），年龄60岁研究了±4年。另一个目的是研究力量训练（ST）对肌肉中这些因子的mRNA水平的影响。糖尿病受试者被随机分为两组。训练（EX）组（8名女性，7名男性）参加了16周的ST，而对照组（CON）组（7名女性，8名男性）仅维持了他们通常的糖尿病护理。非糖尿病受试者作为基线比较组。在糖尿病和非糖尿病受试者之间，体重，腰臀比或血浆TNF-α水平没有差异。糖尿病患者的血浆TNF可溶性受体（sTNFRII）水平较高（P <0.001），肌肉TNF-α（P <0.01），TGF-β1（P <0.01）和IGF-I（P <0.05）mRNA水平较高，比非糖尿病患者要多。 ST导致HbA1c百分比降低（P <0.01），空腹血浆胰岛素降低（P <0.05），无脂肪量（P <0.005）和强度增加（P <0.001）。同样，ST导致TNF-αmRNA表达增加（P <0.05），这与ST诱导的TGF-β1mRNA的增加显着相关（r = 0.86，P <0.001）（P <0.05）。 TGF-β1mRNA的这种增加与IGF-1 mRNA的2倍增加（P <0.001）相关（r = 0.74，P <0.001）。与空腹对照组相比，除空腹胰岛素和TNF-αmRNA以外的所有变化均具有显着性（P <0.05）。两组的空腹血糖，血浆TNF-α或sTNFRII均无变化。因此，作为糖尿病护理的辅助手段，尽管循环TNF-α缺乏变化，肌肉TNF-αmRNA水平却升高，但ST可以改善2型糖尿病西班牙裔老年人的血糖控制。

著录项

  • 作者

    Gordon, Patricia Lee.;

  • 作者单位

    University of Maryland College Park.;

  • 授予单位 University of Maryland College Park.;
  • 学科 Biology Genetics.; Biology Molecular.; Health Sciences Recreation.
  • 学位 Ph.D.
  • 年度 2001
  • 页码 251 p.
  • 总页数 251
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 遗传学;分子遗传学;预防医学、卫生学;
  • 关键词

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