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Microwave detection of breast cancer: A cylindrical configuration for confocal microwave imaging.

机译:乳腺癌的微波检测:用于共聚焦微波成像的圆柱形结构。

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Microwave imaging creates images of electrical property distributions in tissue, and has promise for breast tumor detection due to the contrast in electrical properties of normal and malignant breast tissues and the accessibility of the breast for imaging. Confocal microwave imaging (CMI) is a recently introduced technique that avoids limitations associated with classical microwave imaging. CMI detects areas of increased scatter (e.g. tumors) by scanning the synthetic focus of an array of antennas through the breast. As the object is illuminated with ultra-wideband signals, this corresponds to computing time delays to the focal point, resulting in simple image reconstruction algorithms. Additionally, the resolution is determined primarily by the bandwidth of the illuminating signal, allowing for detection of small tumors with appropriate selection of this bandwidth. CMI appears to be a simple and effective technique for breast tumor detection. The development and evaluation of a new approach to confocal microwave imaging is the contribution of this thesis.; CMI was only very recently introduced, and many key issues need to be addressed. Most importantly, the CMI system must be designed for physical compatibility with the breast examination. The previously introduced CMI system is planar, and involves placing an array of antennas directly on the naturally flattened breast (of a woman who is lying on her back). In this thesis, a cylindrical CMI configuration is developed. A woman lies on her stomach, the breast extends through a hole in the examination table, and is immersed in a low-loss material. The breast is encircled by an array of antennas, which is placed at a distance from the skin. The cylindrical configuration is likely more appropriate for clinical implementation.; The development of cylindrical CMI involves design of appropriate sensing elements and development of image reconstruction algorithms. Construction of appropriate models and simulations of the system are required to test the feasibility of the proposed sensors and algorithms. The finite difference time domain (FDTD) method is well suited to these feasibility studies, as ultra-wideband signals are efficiently simulated in the time domain. In this thesis, four alternative antenna designs are characterized with measures appropriate for ultra-wideband radiation and this specific imaging application. The selected antenna is scanned in a circle around the breast and at a distance from the skin. This is repeated for a number of rows at different heights in order to synthesize a cylindrical or conical array. The returns recorded at each antenna location are processed to reduce clutter, then synthetically focussed at points in the domain of interest. Results indicate that the proposed antenna and algorithms provide the capability to detect and localize (in three dimensions) small spherical tumors at reasonable depths in the breast models. The detection capability achieved with the cylindrical system is comparable to that obtained with the previously introduced planar system.
机译:微波成像产生组织中电特性分布的图像,并且由于正常和恶性乳腺组织的电特性以及成像的乳房可及性方面的差异,有望对乳腺肿瘤进行检测。共聚焦微波成像(CMI)是一种最新引入的技术,可避免与传统微波成像相关的局限性。 CMI通过扫描穿过乳房的一系列天线的合成焦点来检测散射增加的区域(例如肿瘤)。由于对象是用超宽带信号照明的,因此对应于计算到焦点的时间延迟,从而导致了简单的图像重建算法。另外,分辨率主要取决于照明信号的带宽,从而可以通过适当选择该带宽来检测小肿瘤。 CMI似乎是检测乳腺癌的一种简单有效的技术。本文对共焦微波成像新方法的发展和评价进行了贡献。 CMI只是最近才引入的,许多关键问题需要解决。最重要的是,CMI系统必须设计成与乳房检查具有物理兼容性。先前引入的CMI系统是平面的,需要将天线阵列直接放在自然扁平的乳房(躺着的女人的乳房)上。本文提出了一种圆柱形的CMI配置。一个女人躺在她的肚子上,乳房穿过检查台上的一个洞,并浸入低损耗的材料中。乳房被天线阵列包围,天线阵列与皮肤保持一定距离。圆柱形配置可能更适合临床实施。圆柱CMI的开发涉及适当的传感元件的设计和图像重建算法的开发。需要构建适当的模型和系统仿真来测试所提出的传感器和算法的可行性。时域有限差分(FDTD)方法非常适合这些可行性研究,因为可以在时域中高效地模拟超宽带信号。在本文中,对四种替代天线设计进行了表征,并采用了适合超宽带辐射和该特定成像应用的措施。选定的天线绕着乳房围成一圈扫描,并与皮肤保持一定距离。对于不同高度的许多行重复此操作,以合成圆柱形或圆锥形阵列。处理每个天线位置记录的回波以减少杂波,然后综合聚焦在感兴趣域中的点上。结果表明,所提出的天线和算法提供了在乳房模型中的合理深度处检测和定位(在三个维度上)小球形肿瘤的能力。圆柱系统获得的检测能力可与先前引入的平面系统获得的检测能力相媲美。

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