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首页> 外文学位 >The isolation and identification of an oligodendrocyte secreted factor which confers protection to motor neurons.
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The isolation and identification of an oligodendrocyte secreted factor which confers protection to motor neurons.

机译：少突胶质细胞分泌因子的分离和鉴定赋予运动神经元保护作用。

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摘要

It has long been known that one of the functions of the neuronal cells known as oligodendrocytes is to provide the myelin that constitutes the myelin sheath covering the axons of motor neurons. The oligodendrocytes have a native resistance to damage from high levels of nitric oxide (NO) such as those which have been detected in diseases such as Amyotrophic Lateral Sclerosis (ALS) and Multiple Sclerosis (MS) both of which are known as motor neuronal diseases. During co-culture of oligodendrocytes and motor neurons with subsequent high-flux NO assault we found that the oligodendrocytes appeared to perform a second function in relation to motor neurons, they were able to confer protection to the motor neurons and increase their survivability. The protective factor was found to be a secreted factor which was isolated from the spent media of the oligodendrocytes and subsequently identified as the protein lumican.
机译：早就知道，称为少突胶质细胞的神经元细胞的功能之一是提供构成覆盖运动神经元轴突的髓鞘的髓磷脂。少突胶质细胞对高水平的一氧化氮（NO）造成的损害具有天然抵抗力，例如在肌萎缩性侧索硬化症（ALS）和多发性硬化症（MS）等疾病中都检测到的那些，这两种疾病都被称为运动神经元疾病。在少突胶质细胞和运动神经元的共培养以及随后的高通量NO攻击过程中，我们发现少突胶质细胞似乎具有与运动神经元有关的第二功能，它们能够赋予运动神经元以保护作用并提高其生存能力。发现该保护因子是一种分泌因子，其从少突胶质细胞的废培养基中分离出来，随后被鉴定为lumican蛋白。

著录项

  • 作者

    Jeffrey, Stephanie.;

  • 作者单位

    The University of Alabama in Huntsville.;

  • 授予单位 The University of Alabama in Huntsville.;
  • 学科 Neurobiology.
  • 学位 M.S.
  • 年度 2010
  • 页码 103 p.
  • 总页数 103
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 TS97-4;
  • 关键词

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