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首页> 外文学位 >The roles of calcium and iron uptake in egg production by the digenetic trematodes, Echinostoma caproni and Schistosoma mansoni.
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The roles of calcium and iron uptake in egg production by the digenetic trematodes, Echinostoma caproni and Schistosoma mansoni.

机译：钙和铁在双生吸虫，卡氏棘皮虫和曼氏血吸虫的产卵中的作用。

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摘要

Digenetic trematodes form a large group of medically important mammalian parasites. Production of eggs by digenes is required for continuation of the parasite lifecycle (transmission) and, for heterophyids, lung flukes and schistosomes, is an effector of host pathology. Although the pathway leading to egg production in digenes has been described, regulation of the process is not well understood. This work addresses whether iron and calcium, two ubiquitous regulatory agents in eukaryotes, are involved in the reproduction of digenetic trematodes.;The affect of supplemental iron on in vitro egg production of the intestinal parasite, Echinostoma caproni, was evaluated in a defined culture system. The results suggest that internal iron stores, not uptake of environmental iron, are used to sustain reproductive activity in culture. Methods for defining the role of iron uptake in trematode egg production are discussed.;The effect of pharmacological blockade of calcium influx on the in vitro production of eggs by Echinostoma caproni and Schistosoma mansoni was investigated. The results indicate that egg production by these digenes requires influx of calcium, and that this uptake can be inhibited by drugs that block mammalian calcium channels. This suggests that calcium channel blockers may provide a novel means of interrupting digene reproduction and consequent pathogenesis and transmission.
机译：双基因吸虫形成一大群医学上重要的哺乳动物寄生虫。持续寄生虫生命周期（传播）需要由双基因生产卵，对于异质类，肺吸虫和血吸虫，这是宿主病理学的影响因素。尽管已描述了导致双基因产卵的途径，但对该过程的调节尚不甚了解。这项工作解决了真核生物中两种普遍存在的调节剂铁和钙是否参与了双基因吸虫的繁殖;;在确定的培养系统中评估了补充铁对肠道寄生虫埃氏棘皮oma虫卵体外产卵的影响。 。结果表明，内部铁存储而不是环境铁的吸收被用于维持培养物中的繁殖活动。讨论了定义铁吸收在吸虫卵生产中的作用的方法。；研究了钙离子流入的药理学阻断作用对卡氏棘皮动物和曼氏血吸虫体外培养卵的影响。结果表明，这些双基因产生的卵需要钙的流入，并且这种吸收可以被阻断哺乳动物钙通道的药物抑制。这表明钙通道阻滞剂可能提供一种中断双基因繁殖以及随后的发病机理和传播的新颖手段。

著录项

  • 作者

    Walter, Mark.;

  • 作者单位

    University of California, Santa Barbara.;

  • 授予单位 University of California, Santa Barbara.;
  • 学科 Biology Microbiology.
  • 学位 Ph.D.
  • 年度 2000
  • 页码 42 p.
  • 总页数 42
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

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