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Evidence for a relationship between the suppression of distortion product otoacoustic emissions and hearing threshold.

机译：失真产物耳声发射的抑制与听力阈值之间存在关系的证据。

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摘要

Otoacoustic emissions are sounds produced by the cochlea of the inner ear. For example, if two tonal stimuli at frequencies f1 and f 2 are presented to the ear, a third spectral component can be measured in the ear canal at frequency 2f1-f2, named the cubic distortion product otoacoustic emission (DPOAE). For low levels of f 1 and f2, the dominant cause of distortion is believed to be the nonlinear operation of the cochlear amplifier, the biochemically-powered internal motor behind the ear's remarkable frequency selectivity and sensitivity. Since most cases of hearing loss result from an impairment of this amplification process, DPOAEs provide a fast, objective test of hearing status. However, because their levels correlate only weakly with audiometric thresholds, use of DPOAEs in the clinic is limited to a pass or fail screening for hearing defects.; In a recent paper, David Mills (J Acoust Soc Am 103:507–523) proposed a novel algorithm for estimating the gain of the cochlear amplifier, not from DPOAE level, but from the manner in which the level decreased when a third stimulus tone, the suppressor, was applied simultaneously with f1 and f2. In this thesis, the validity of Mills' algorithm is investigated using two approaches. First, a relationship between suppression and gain is derived on the basis of a small number of assumptions motivated by established empirical findings. Second, it is shown, to a very high degree of certainty, that there exists a relationship between DPOAE suppressibility and hearing threshold (an indirect measure of active gain) in humans. It is concluded that DPOAE suppression is a direct, noninvasive window on the gain of the cochlear amplifier. It has tangible diagnostic potential and warrants further study.
机译：耳声是由内耳的耳蜗产生的声音。例如，如果向耳朵呈现频率为f 1 和f 2 的两个音调刺激，则可以在耳道中以2f 1 -f 2 ，称为立方畸变产物耳声发射（DPOAE）。对于低水平的f 1 和f 2 ，认为失真的主要原因是耳蜗放大器的非线性操作，耳蜗是耳后的生化动力内部马达出色的频率选择性和灵敏度。由于大多数听力损失病例是由这种扩增过程的损害引起的，因此DPOAE可提供一种快速，客观的听力状态测试。但是，由于它们的水平与听力阈值之间的相关性很弱，因此在临床中DPOAE的使用仅限于通过或未通过听力障碍筛查。在最近的一篇论文中，David Mills（J Acoust Soc Am 103：507-523）提出了一种新颖的算法，用于估计耳蜗放大器的增益，而不是根据DPOAE电平，而是根据第三种刺激音时电平降低的方式来估算抑制剂，与f 1 和f 2 同时使用。本文采用两种方法研究了密尔斯算法的有效性。首先，抑制和增益之间的关系是基于已建立的经验发现所激发的少量假设而得出的。第二，在高度确定性上表明，人类中DPOAE的抑制性与听力阈值（活动增益的间接度量）之间存在关系。结论是，DPOAE抑制是耳蜗放大器增益的直接，非侵入性窗口。它具有明显的诊断潜力，值得进一步研究。

著录项

  • 作者

    Pienkowski, Martin.;

  • 作者单位

    University of Toronto (Canada).;

  • 授予单位 University of Toronto (Canada).;
  • 学科 Biology Animal Physiology.; Health Sciences Audiology.
  • 学位 M.Sc.
  • 年度 2000
  • 页码 99 p.
  • 总页数 99
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 生理学;耳科学、耳疾病;
  • 关键词

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