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首页> 外文学位 >Exercise-induced regulation of brain-derived neurotrophic factor (BDNF) gene expression in the rat hippocampus.
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Exercise-induced regulation of brain-derived neurotrophic factor (BDNF) gene expression in the rat hippocampus.

机译：运动诱导的大鼠海马中脑源性神经营养因子（BDNF）基因表达的调节。

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摘要

Exercise is associated with enhanced cognitive function and maintenance of cognitive health. The molecular mechanisms underlying this improved brain functioning are beginning to be identified. Our research suggests that regulation of growth factor expression in the central nervous system may be one mechanism by which exercise can improve brain health and function. Physical activity (exercise) increases gene expression of brain-derived neurotrophic factor (BDNF), and this effect is particularly prominent in the hippocampus, a brain region associated with learning and memory rather than motor function. The goal of my studies has been to characterize the effect of physical activity on regulation of BDNF gene expression in the rat hippocampus, using voluntary wheel running as the exercise model.; The studies presented in this thesis explore variables that influence BDNF gene regulation in response to physical activity. Upregulation of BDNF gene expression in the hippocampus is a reproducible response to exercise across animal strains, sex, and species. BDNF gene upregulation by exercise is consistent under a variety of exercise conditions, such as duration of the exercise period, from hours to days and weeks. The effect is rapid, occurring within hours, and sustained. Voluntary exercise differentially increases the expression of multiple BDNF transcript forms. Exon I-BDNF and exon-II BDNF transcripts are selectively increased after 6 and 12 hours of running. Cholinergic and GABAergic input to the hippocampus from the medial septum provide a tonic regulation of BDNF gene expression in the hippocampus. Removal or reduction of cholinergic and GABAergic septohippocampal input reduces baseline BDNF gene activity, and blocks exercise-dependent increases in BDNF gene expression, particularly in the dentate gyrus and hilus of the hippocampus. Unexpectedly, the GABAergic input appears relatively more important than the cholinergic afferents in this effect. In addition, exercise and estrogen interact to modulate BDNF gene expression. In the absence of estrogen, exercise increases hippocampal BDNF gene expression only during a critical window of time. Finally, the presence of estrogen increases both BDNF gene expression as well as physical activity levels.; These data provide an initial characterization of the exercise-associated regulation of BDNF gene expression, a molecule increasingly recognized for its critical role in neuroprotection and synaptic plasticity.
机译：运动与增强的认知功能和维持认知健康有关。开始确定这种改善的脑功能的分子机制。我们的研究表明，调节中枢神经系统中生长因子的表达可能是运动可以改善大脑健康和功能的一种机制。身体活动（运动）会增加脑源性神经营养因子（BDNF）的基因表达，这种作用在海马体中尤为突出，海马体是与学习和记忆而非运动功能相关的大脑区域。我的研究目标是使用自愿性轮转运动作为锻炼模型来表征体育锻炼对大鼠海马中BDNF基因表达调控的影响。本论文中的研究探索了影响BDNF基因调节以响应体育活动的变量。海马中BDNF基因表达的上调是对跨动物品系，性别和物种运动的可再现反应。在各种运动条件下，例如运动时间，从数小时到数天和数周，运动引起的BDNF基因上调是一致的。效果是迅速的，在数小时内发生并且持续。自愿运动有区别地增加了多种BDNF转录形式的表达。运行6和12小时后，外显子I-BDNF和外显子II BDNF转录物选择性增加。从中隔到海马的胆碱能和GABA能输入提供了海马中BDNF基因表达的补品调节。去除或减少胆碱能和GABA能的海马输入减少了基线BDNF基因的活性，并阻止了BDNF基因表达的运动依赖性增加，特别是在海马的齿状回和希尔斯。出乎意料的是，在这种作用下，GABA能输入比胆碱能输入相对重要。另外，运动和雌激素相互作用以调节BDNF基因表达。在没有雌激素的情况下，运动仅在关键时间段内增加海马BDNF基因表达。最后，雌激素的存在增加了BDNF基因的表达以及身体活动水平。这些数据提供了与运动相关的BDNF基因表达调控的初步表征，BDNF基因表达由于其在神经保护和突触可塑性中的关键作用而日益得到认可。

著录项

  • 作者

    Berchtold, Nicole Claudia.;

  • 作者单位

    University of California, Irvine.;

  • 授予单位 University of California, Irvine.;
  • 学科 Biology Neuroscience.; Health Sciences Recreation.
  • 学位 Ph.D.
  • 年度 2000
  • 页码 180 p.
  • 总页数 180
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 神经科学;预防医学、卫生学;
  • 关键词

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