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Development of a multi-mode optical imaging system for preclinical applications in vivo.

机译：用于体内临床前应用的多模式光学成像系统的开发。

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摘要

This thesis reports advanced optical imaging technology in a stand-alone system that enables functional mesoscopic imaging (whole-body or endoscopic imaging with microscopic resolution) of small animals in vivo, and provides for quantitative, dynamic, and functional monitoring of chemo- and nanoconstruct therapy. Many currently available imaging approaches have been applied to preclinical studies of cancer, stem cells, and pharmaceutical outcomes. Moreover, useful in vivo imaging may require several, preferably combined, and advanced imaging modalities to examine different but complementary characteristics of molecules, cells, or tissues. Although commercial systems perform well for standard imaging of small animals, they have limitations stemming from being single-modality instruments. Thus, a new multimode optical imaging system that is designed to be application-optimizable, with higher sensitivity and specificity has been developed here in order to overcome these limitations. The instrument combines various in vivo imaging modes, including fluorescence intensity, spectral, lifetime, intra-vital confocal, two-photon excited fluorescence, and bioluminescence imaging. Also this system is a unique and comprehensive imaging platform for analyzing kinetic, quantitative, environmental, and other highly-relevant information with macro- to micro-scopic resolution. This system can be optimized for various applications, and the combination of multiple imaging modes for increased contrast and complementary/synergetic information in chemotherapy assessment and cancer detection is emphasized here.
机译：本论文报告了在独立系统中的先进光学成像技术，该技术可以在体内对小动物进行功能性介观成像（具有微观分辨率的全身或内窥镜成像），并提供化学，纳米结构的定量，动态和功能监控治疗。许多当前可用的成像方法已应用于癌症，干细胞和药物治疗的临床前研究。此外，有用的体内成像可能需要几种（最好是组合的）先进的成像方式来检查分子，细胞或组织的不同但互补的特征。尽管商业系统对于小型动物的标准成像表现良好，但由于其是单模态仪器，因此存在局限性。因此，这里已经开发了一种新的多模光学成像系统，该系统设计为应用可优化的，具有更高的灵敏度和特异性，以克服这些限制。该仪器结合了多种体内成像模式，包括荧光强度，光谱，寿命，体内共聚焦，双光子激发荧光和生物发光成像。此外，该系统还是一个独特而全面的成像平台，可用于从宏观到微观的分辨率分析动力学，定量，环境和其他高度相关的信息。该系统可以针对各种应用进行优化，在此强调在化疗评估和癌症检测中用于增强对比度和互补/协同信息的多种成像模式的组合。

著录项

  • 作者

    Hwang, Jae Youn.;

  • 作者单位

    University of Southern California.;

  • 授予单位 University of Southern California.;
  • 学科 Engineering Biomedical.
  • 学位 Ph.D.
  • 年度 2009
  • 页码 142 p.
  • 总页数 142
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 生物医学工程;
  • 关键词

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