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首页> 外文学位 >Numerical modeling of blood flow in human left coronary artery and in vitro study of endothelial cell activation by shear stress.
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Numerical modeling of blood flow in human left coronary artery and in vitro study of endothelial cell activation by shear stress.

机译：人左冠状动脉血流的数值模拟和剪切应力激活内皮细胞的体外研究。

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Scope and method of study. The major scope of this study was to estimate the wall shear stress (WSS) distribution inside the left anterior descending (LAD) artery under normal and disease conditions. The LAD models (2D and 3D models) were constructed based on previous studies. This assisted in predicting the deviation of WSS estimation due to the selection of LAD model. The WSS distribution was estimated by computational fluid dynamic analysis of blood flow in LAD using FLUENT. The other purpose of this study was to understand the activation response behavior of endothelial cells (EC) exposed to varying shear stress. A cone and plate hemodynamic cell shearing device was used to shear the EC, based on WSS information from numerical simulation. The EC activation was measured based on their inflammatory response i.e., the amount of surface protein (ICAM-1 and TF) expressed.;Findings and conclusions. From the numerical studies, disturbed WSS distribution was found near the throat region. The WSS reached a peak value of around 14Pa at the center of throat in 80% stenosis condition. The recirculation zone formed downstream the throat possessed a low oscillating shear stress region. Besides, the 2D and 3D models estimated fairly similar results in the upstream location under normal and stenosis conditions but deviated near the throat region. It can be concluded that 2D model was sufficient for WSS estimation under normal conditions but not suggestible for disease conditions. The in vitro results revealed the EC activation and increased ICAM-1 expression when exposed to low oscillating shear stress (inside recirculation zone). Finally, the high WSS gradient in near the throat region and EC activation inside the recirculation zone may cause the lesion growth towards the downstream direction.
机译：研究范围和方法。这项研究的主要范围是估计正常和疾病情况下左前降支（LAD）动脉内的壁切应力（WSS）分布。 LAD模型（2D和3D模型）是基于先前的研究构建的。由于选择了LAD模型，这有助于预测WSS估计的偏差。通过使用FLUENT对LAD中的血流进行计算流体动力学分析来估计WSS分布。这项研究的另一个目的是了解暴露于变化的切应力的内皮细胞（EC）的激活反应行为。基于数值模拟的WSS信息，使用锥板式血流动力学细胞剪切装置剪切EC。根据其炎症反应，即表达的表面蛋白（ICAM-1和TF）的量来测量EC的活化。结果和结论。通过数值研究，在喉部附近发现了WSS分布不均。在80％狭窄的情况下，WSS在喉咙中心达到14Pa左右的峰值。在喉咙下游形成的再循环区具有低的振荡剪切应力区域。此外，在正常和狭窄条件下，2D和3D模型在上游位置的估计结果相当相似，但在喉咙区域附近出现偏差。可以得出结论，在正常条件下，二维模型足以进行WSS估计，但对于疾病条件却不可行。体外结果显示，当暴露于低振荡剪切应力（在再循环区域内）时，EC激活并增加了ICAM-1表达。最后，在喉咙区域附近的高WSS梯度和再循环区域内部的EC激活可能导致病变向下游方向生长。

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