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首页> 外文学位 >Chronic effects of single intra-peritoneal injection of endosulfan on rainbow trout (Oncorhynchus mykiss) and field observations of caged rainbow trout in Oshawa Creek.
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Chronic effects of single intra-peritoneal injection of endosulfan on rainbow trout (Oncorhynchus mykiss) and field observations of caged rainbow trout in Oshawa Creek.

机译：腹膜内注射硫丹对虹鳟鱼（Oncorhynchus mykiss）的长期影响以及奥沙瓦河中笼养虹鳟的野外观察。

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摘要

The organochlorine pesticide endosulfan has been shown to be highly toxic to fish and there is some evidence to support that it may act as an endocrine disrupting chemical. Juvenile rainbow trout (Oncorhynchus mykiss) were caged at 4 sites in Oshawa Creek during the fall and spring of 2008 and 2009 while another group was intra-peritoneal injected in the laboratory with varying concentrations (ppm) of endosulfan. Plasma vitellogenin (VTG) levels, liver ethoxyresorufin-O-deethylase (EROD), citrate synthase (CS), lactate dehydrogenase (LDH), and brain acetylcholine esterase (AChE) (caged fish only) enzymatic activities were measured. Trout injected with endosulfan experienced an increase of the anaerobic (LDH activity) and a decrease of the aerobic (CS activity) metabolic pathways, while male VTG levels increased. Since it was a singular injection, VTG results have to be confirmed. Fall caged trout showed increased EROD activity and inhibited AChE activity while those caged in the spring experienced an unexpected exposure to the lampricide 3-Trifluoro-Methyl-4-Nitro-Phenol (TFM) which disrupted metabolic parameters (inhibited CS and increased LDH activity). Both fall and spring caged trout experienced no induction of VTG activity. Further research is needed since the spring exposure was altered due to the unplanned TFM treatment and thus did not represent a valid temporal replicate.
机译：已证明有机氯农药硫丹对鱼类有剧毒，并且有一些证据支持它可能会破坏内分泌。在2008年秋季和春季以及2009年春季和春季，奥沙瓦河（Oshawa Creek）的4个地点将幼年虹鳟（Oncorhynchus mykiss）关在笼子里，而另一组腹腔内注射了不同浓度的硫丹（ppm）。测量了血浆卵黄蛋白原（VTG）水平，肝乙氧基间苯二酚-O-脱乙基酶（EROD），柠檬酸合酶（CS），乳酸脱氢酶（LDH）和脑乙酰胆碱酯酶（AChE）（仅笼养鱼）的酶活性。注射硫丹的鳟鱼的厌氧（LDH活性）增加，有氧（CS活性）代谢途径减少，而雄性VTG水平增加。由于是单次注射，因此必须确认VTG结果。秋季笼养的鳟鱼显示出EROD活性增加，并抑制了AChE活性，而春季笼养的鳟鱼则意外暴露于除草剂3-三氟甲基-4-硝基苯酚（TFM）中，这破坏了代谢参数（抑制了CS和LDH活性增加） 。秋季和春季笼养鳟鱼均未诱导VTG活性。由于春天的暴露由于计划外的TFM处理而改变，因此不能代表有效的时间复制，因此需要进一步的研究。

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  • 作者

    Armour, Jeffrey Andrew.;

  • 作者单位

    University of Ontario Institute of Technology (Canada).;

  • 授予单位 University of Ontario Institute of Technology (Canada).;
  • 学科 Biology Molecular.Chemistry Biochemistry.Biology Ecology.
  • 学位 M.Sc.
  • 年度 2009
  • 页码 137 p.
  • 总页数 137
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

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