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Toxicity risks associated with petrochemical wastes; based on resident cotton rats (Sigmodon hispidus).

机译：与石化废物有关的毒性风险；基于常驻棉鼠（Sigmodon hispidus）。

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摘要

Scope and method of study. Current research of our group is directed at studying the potential health effects of exposure to environmental contaminants associated with petrochemical wastes. The purpose of this study was (1) to evaluate the sensitivity of histopathological examination for detecting toxicity in cotton rats; (2) to assess toxicity risks associated with chronic exposure to fluoride by monitoring dental lesions in cotton rats; (3) to develop and validate a reproducible assay for evaluating responsiveness of bone marrow progenitor cells of the cotton rat to bone marrow toxicants; and (4) to evaluate the previous assay in our field study to investigate the impact of environmental contamination induced by petrochemical wastes. We monitored pathologic response of cotton rats in situ by seasonally collecting resident animals from replicated petrochemical waste sites and ecologically matched reference sites in Oklahoma over three years.;Findings and conclusions. Evaluation of environmental hazard of industrial waste sites using morphological and histopathological parameters of cotton rats were not sensitive enough to detect subtle toxicity induced by exposure to petrochemical wastes. Cotton rats inhabiting petrochemical waste sites contaminated with fluoride had substantial risks of developing dental fluorosis. We detected significant suppression of bone marrow granulocyte-macrophage progenitor cells in cotton rats exposed to petrochemical wastes. This result suggested that in vitro bone marrow progenitor culture could be served as one of the most sensitive indicators for study of ecotoxicity risks associated with environmental contaminants. The findings of our study will be useful in assessing risks to terrestrial ecosystem and in making predictions regarding human health risks.
机译：研究范围和方法。我们小组的当前研究旨在研究与石化废物相关的环境污染物的潜在健康影响。这项研究的目的是（1）评估组织病理学检查对棉花大鼠毒性检测的敏感性； （2）通过监测棉鼠的牙齿损伤来评估与长期暴露于氟化物有关的毒性风险； （3）开发和验证可重复的测定方法，以评估棉鼠的骨髓祖细胞对骨髓毒物的反应性； （4）评估我们现场研究中的先前分析方法，以调查石化废物引起的环境污染的影响。我们通过在三年内季节性地从俄克拉荷马州的重复石化废物场所和生态匹配的参考场所收集常驻动物来监测原位棉花大鼠的病理反应。研究结果和结论。使用形态学和组织病理学参数评估棉鼠的工业废物场对环境的危害不够灵敏，无法检测出暴露于石化废物引起的细微毒性。居住在被氟化物污染的石化废料场中的棉鼠有发生氟中毒的巨大风险。我们在暴露于石化废物的棉花大鼠中检测到骨髓粒细胞巨噬细胞祖细胞的显着抑制。该结果表明，体外骨髓祖细胞培养可以作为研究与环境污染物相关的生态毒性风险的最敏感指标之一。我们研究的结果将有助于评估陆地生态系统的风险以及做出有关人类健康风险的预测。

著录项

  • 作者

    Kim, Soochong.;

  • 作者单位

    Oklahoma State University.;

  • 授予单位 Oklahoma State University.;
  • 学科 Biology Veterinary Science.;Environmental Sciences.;Health Sciences Toxicology.;Health Sciences Pathology.
  • 学位 Ph.D.
  • 年度 1999
  • 页码 112 p.
  • 总页数 112
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

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