• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文学位 >Advanced polymer-based microfabricated neural probes using biologically driven designs.
【24h】

Advanced polymer-based microfabricated neural probes using biologically driven designs.

机译：采用生物驱动设计的先进的基于聚合物的微细加工神经探针。

获取原文
获取原文并翻译 | 示例
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

This research presents new designs and materials for neural recording and stimulation technology. Greater electrode density is enabling neuroscientists to study larger neuronal populations, but even higher signal stability and electrode density are needed. Addressing these issues is critically important for neuroprostheses in the treatment of spinal cord injury, ALS, or limb loss. Stimulating electrodes have already improved quality of life for those with Parkinson's and dystonia and this technology has many new indications on the horizon. Smaller stimulating electrodes with reduced glial encapsulation would reduce the power requirements of these applications. I will discuss how our research impacts neurotechnology by enabling reduced glial encapsulation, greater design options, and improved electrical insulation.;Our first study introduced a novel neural probe with reduced chronic cellular encapsulation. We hypothesized that if a structural feature size is smaller than a reactive cell body (7 microm), the resulting encapsulation would be mitigated by the prevention of cellular spreading. We investigated this relationship between size and tissue reactivity using a microfabricated parylene structure. Probes were implanted in the rat neocortex for four weeks followed by histological analysis. We found the non-neuronal density around the sub-cellular feature was less than half of that around the probe shank.;The objective of our second study was to identify a parylene process that would enable long-term bioelectrical insulation. We contrasted parylene-C with an alternative parylene material using electrical and mechanical tests. We present a reactive parylene (complementary layers of PPX-CHO and PPX-CH 2NH2) that can be used in conjunction with parylene-C but has improved electrical insulation and wet metal adhesion.;In our third study, a new parylene-based microfabrication process is presented for neural recording, stimulation, and drug delivery applications. We introduce a large design space for electrode placement and structural flexibility with a six mask process. By using chemical mechanical planarization, electrodes may be created top-side, back-side, or on edge having three sides. Poly(3,4-ethylenedioxythiophene) (PEDOT) modified edge electrodes having an 85 microm2 footprint (smallest reported to date) resulted in an impedance of 200 kO at 1kHz. Edge electrodes successfully recorded single unit activity in acute animal studies.
机译：这项研究提出了用于神经记录和刺激技术的新设计和新材料。更高的电极密度使神经科学家能够研究更大的神经元种群，但还需要更高的信号稳定性和电极密度。解决这些问题对于神经假体在治疗脊髓损伤，ALS或肢体脱落方面至关重要。刺激性电极已经改善了帕金森氏症和肌张力障碍患者的生活质量，这项技术有许多新的迹象。具有减小的神经胶质封装的较小的刺激电极将降低这些应用的功率需求。我将讨论我们的研究如何通过减少胶质细胞的包裹，更多的设计选择和改善的电绝缘性来影响神经技术。我们的第一项研究介绍了一种新型的减少慢性细胞包裹的神经探针。我们假设，如果结构特征尺寸小于反应性细胞体（<7微米），则可以通过防止细胞扩散来减轻产生的包囊。我们研究了使用微米级聚对二甲苯结构的尺寸与组织反应性之间的关系。将探针植入大鼠新皮层4周，然后进行组织学分析。我们发现亚细胞特征周围的非神经元密度小于探针柄周围的非神经元密度。我们的第二项研究的目的是确定能够实现长期生物电绝缘的聚对二甲苯过程。我们通过电气和机械测试将聚对二甲苯-C与替代聚对二甲苯材料进行了对比。我们提出了一种反应性聚对二甲苯（PPX-CHO和PPX-CH 2NH2的互补层），可以与聚对二甲苯-C结合使用，但具有改善的电绝缘性和湿金属附着力。提出了用于神经记录，刺激和药物递送应用的过程。我们通过六个掩膜工艺为电极放置和结构灵活性引入了较大的设计空间。通过使用化学机械平面化，可以在顶侧，背侧或具有三个侧面的边缘上创建电极。聚（3,4-乙撑二氧噻吩）（PEDOT）修饰的边电极具有85 microm2的占地面积（迄今为止最小的报道），在1kHz时的阻抗为200 kO。边缘电极在急性动物研究中成功记录了单个单位的活动。

著录项

  • 作者

    Seymour, John P.;

  • 作者单位

    University of Michigan.;

  • 授予单位 University of Michigan.;
  • 学科 Engineering Biomedical.;Engineering Electronics and Electrical.
  • 学位 Ph.D.
  • 年度 2009
  • 页码 129 p.
  • 总页数 129
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 生物医学工程;无线电电子学、电信技术;
  • 关键词

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号