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首页> 外文学位 >Plasticity in the maternal circuit: Effects of pup exposure and retention interval on astrocyte numbers in primiparous and multiparous animals.
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Plasticity in the maternal circuit: Effects of pup exposure and retention interval on astrocyte numbers in primiparous and multiparous animals.

机译：母体回路中的可塑性：幼仔和多胎动物中幼崽暴露和保留间隔对星形胶质细胞数量的影响。

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摘要

Experience with pups postpartum enhances the expression of maternal behavior up to a month later. These long-term behavioral changes are accompanied by long-term changes in immunohistochemical expression of neuronal and glial proteins, specifically Fos, Protein Kinase C (PKC), and Glial Fibrillary Acidic Protein (GFAP) in the medial preoptic area.; The goal of the present study was to examine astrocytic changes (as assessed by Glial Fibrillary Acidic Protein) following varying amounts of maternal experience and over a longer time-frame. Primiparous and multiparous animals (2x pregnant), were given a brief exposure (either 2 or 24 hours) to 1-3 day old rat pups the day following parturition, or were given a similar control manipulation. Animals were then sacrificed and subjected to immunohistochemistry either 1 day, 5 days or 10 days following postpartum pup exposure.; A main effect for parity in favor of multiparous animals was seen in the MPOA. An opposite effect for parity was found in the medial and lateral habenula, as well as the medial amygdala (MEA), with primiparous animals having higher numbers of astrocytes than multiparous animals. Parity differences in the MPOA were slight at one day after exposure/manipulation, but were significantly different at day five. At day ten, parity differences were seen, but were dependent upon pup exposure. In contrast, in the MEA and habenula nuclei, parity differences were most substantial at day one.; The results suggest that primiparous and multiparous animals differ not only in what they learn, as evidenced from the dissociation between MPOA and MEA/habenula brain regions, but also differ in terms of when learning takes place.
机译：产后幼崽的经历可在一个月后增强产妇行为的表达。这些长期的行为变化伴随着神经和神经胶质蛋白的免疫组织化学表达的长期变化，特别是内侧视前区的Fos，蛋白激酶C（PKC）和神经胶质原纤维酸性蛋白（GFAP）。本研究的目的是检查产妇经验变化后和较长时间内的星形胶质细胞变化（通过神经胶质纤维酸性蛋白评估）。在分娩后的第二天，将初生和多胎动物（怀孕2x），短暂暴露（2或24小时）至1-3日龄的幼崽，或进行类似的对照操作。然后处死动物，并在产后幼犬暴露后1天，5天或10天进行免疫组织化学分析。在MPOA中看到了对多胎动物有利于均等的主要作用。在内侧和外侧ha管以及内侧杏仁核（MEA）中发现了对胎次的相反作用，其中初生动物的星形胶质细胞数量多于多生动物。接触/操作后一天，MPOA的奇偶性差异很小，但在第五天时差异显着。在第10天，观察到同等差异，但取决于幼崽的暴露程度。相反，在MEA和哈贝努核中，第一天的奇偶性差异最大。结果表明，初生动物和多生动物不仅在学习方面有所不同（从MPOA与MEA /羽扇脑区域之间的分离中可以证明），而且在学习的时间方面也有所不同。

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  • 作者

    Featherstone, Robert Earle.;

  • 作者单位

    University of Toronto (Canada).;

  • 授予单位 University of Toronto (Canada).;
  • 学科 Biology Neuroscience.
  • 学位 M.A.
  • 年度 1997
  • 页码 66 p.
  • 总页数 66
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

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