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A Bayesian approach to biokinetic models of internally-deposited radionuclides.

机译:内部沉积放射性核素生物动力学模型的贝叶斯方法。

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摘要

ayesian methods were developed and applied to estimate parameters of biokinetic models of internally deposited radionuclides for the first time. Marginal posterior densities for the parameters, given the available data, were obtained and graphed. These densities contain all the information available about the parameters and fully describe their uncertainties. Two different numerical integration methods were employed to approximate the multi-dimensional integrals needed to obtain these densities and to verify our results. One numerical method was based on Gaussian quadrature. The other method was a lattice rule that was developed by Conroy. The lattice rule method is applied here for the first time in conjunction with Bayesian analysis. Computer codes were developed in Mathematica's own programming language to perform the integrals. Several biokinetic models were studied. The first model was a single power function, ;The second model was a single exponential function,
机译:开发了ayesian方法并将其首次用于估算内部沉积的放射性核素的生物动力学模型的参数。在给定可用数据的情况下,获得参数的边缘后验密度并绘制图形。这些密度包含有关参数的所有可用信息,并充分描述了其不确定性。使用两种不同的数值积分方法来近似获得这些密度所需的多维积分并验证我们的结果。一种数值方法是基于高斯正交的。另一种方法是由Conroy开发的晶格法则。首次将格律规则方法与贝叶斯分析结合使用。用Mathematica自己的编程语言开发了计算机代码以执行积分。研究了几种生物动力学模型。第一个模型是单个幂函数;第二个模型是单个指数函数,

著录项

  • 作者

    Amer, Mamun F.;

  • 作者单位

    The University of Tennessee.;

  • 授予单位 The University of Tennessee.;
  • 学科 Nuclear engineering.;Biophysics.;Nuclear physics and radiation.
  • 学位 Ph.D.
  • 年度 1997
  • 页码 128 p.
  • 总页数 128
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

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