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首页> 外文学位 >Etude de l'activite biologique des plantes medicinales de la flore rwandaise: Maesa lanceolata Forsskal var. golungensis Welw. et Ipomoea involucrata P. Beauv.
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Etude de l'activite biologique des plantes medicinales de la flore rwandaise: Maesa lanceolata Forsskal var. golungensis Welw. et Ipomoea involucrata P. Beauv.

机译：卢旺达植物区系药用植物的生物活性研究：毛叶枫木（Maesa lanceolata Forsskal var。）。哥伦山韦尔夫和番薯（Ipomoea involucrata P. Beauv）。

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摘要

The plants used in folk medicine possess real therapeutical properties and have been an important source of drugs for a long time. They offer excellent perspectives for the discovery of new pharmaceutical drugs, in particular anti-infectious agents. Furthermore, the majority of the Rwandan population, like elsewhere in the Third-World, are dependent on traditional medicine for their primary health care. These facts prompted us to undertake a study on the antiviral activity of seven plants, currently used by Rwandan healers.; In a preliminary antiviral screening against a battery of six viruses (enveloped and non-enveloped viruses), Maesa lanceolata and Ipomoea involucrata exhibited an interesting antiviral activity against enveloped viruses. In a bioassay-guided purification using HSV 1 as target model, two virucidal saponin mixtures against HSV 1, HSV 2 and VSV T2 were isolated from M. lanceolata, whereas an antiherpetic (HSV 1 and 2) glycosidic resin and two non-identified fractions showing a moderate anti-HIV activity were obtained from I. involucrata. The saponin mixture MC3B1 showed a potent haemolytic and molluscicidal activity but also mild fungistatic and antimutagenic effects. The sapogenine mixture obtained upon acidic hydrolysis of MC3B1 was not active. The combination of both saponin mixtures as found naturally in M. lanceolata, showed higher virucidal activity than either of the mixtures separately. MC3B1 contains six homologous oleanan type saponins, characterized by MS, {dollar}sp1{dollar}H-, {dollar}sp{lcub}13{rcub}{dollar}C- and 2D-NMR. The glycosidic resin (IEY2B5A) isolated from I. involucrata exerted a high true antiviral activity against HSV 1 and HSV 2. To our knowledge, such an activity has not been reported yet for this class of compounds. The fractions IDZ1 and IDZ2 exhibited moderate anti-HIV activity. The saponins from M. lanceolata as well as the glycosidic resin from I. involucrata have significant cytotoxicity, while IDZ1 and IDZ2 show a reasonable selectivity.; Haemolyzing saponins are regarded as useful oral hypocholesterolaemic agents, suggesting that MC3B1 could find a possible clinical application. Like aescine, MC3B1 could be used as anti-oedematious in the treatment of symptoms related to the veino-lymphatic system failure. M. lanceolata would, in addition, play a major role in schistosomiasis prevention by a local control of the aquatic snail vector. Glycosidic resins from Convolvulaceae have been reported to show an antitumor activity, like most true antivirals. I. involucrata resin is worth being tested for that interesting property.
机译：民间医学中使用的植物具有真正的治疗特性，并且长期以来一直是重要的药物来源。它们为发现新的药物特别是抗感染剂提供了极好的前景。此外，与第三世界的其他地方一样，卢旺达的大多数人口都依赖传统医学来提供基本的医疗保健。这些事实促使我们对卢旺达治疗者目前使用的七种植物的抗病毒活性进行了研究。在针对一系列六种病毒（包膜和非包膜病毒）的初步抗病毒筛选中，轮叶前鞭毛虫和小叶番薯显示出对包膜病毒的有趣抗病毒活性。在以HSV 1为目标模型的生物测定指导纯化中，从轮叶分枝杆菌中分离了两种针对HSV 1，HSV 2和VSV T2的杀虫皂苷混合物，而抗疱疹药（HSV 1和2）糖苷树脂和两个未鉴定的馏分表现出适度的抗HIV活性的是从总产肠杆菌。皂苷混合物MC3B1表现出强大的溶血和杀软体动物活性，但也具有温和的抑真菌和抗诱变作用。酸性水解MC3B1时获得的皂树碱混合物没有活性。在轮叶分枝杆菌中天然发现的两种皂苷混合物的组合显示出比单独的任何一种混合物更高的杀病毒活性。 MC3B1包含六个同源的齐墩果型皂苷，其特征在于MS，{sp1} {1} H-，{sp} 1} 13 {rcub} {C}和2D-NMR。从棉铃虫中分离出的糖苷树脂（IEY2B5A）对HSV 1和HSV 2具有很高的真实抗病毒活性。据我们所知，此类化合物尚未报道这种活性。馏分IDZ1和IDZ2表现出中等的抗HIV活性。轮叶M. lanceolata的皂苷和in毛糖I. involucrata的糖苷树脂具有明显的细胞毒性，而IDZ1和IDZ2具有合理的选择性。溶血皂苷被认为是有用的口服降胆固醇药，表明MC3B1可能找到可能的临床应用。像七叶皂苷一样，MC3B1可用作抗水肿治疗与静脉-淋巴系统衰竭有关的症状。此外，通过对水生蜗牛媒介的局部控制，轮叶分枝杆菌将在血吸虫病的预防中发挥重要作用。据报道，旋花科的糖苷树脂显示出抗肿瘤活性，就像大多数真正的抗病毒药一样。 I. involucrata树脂因其有趣的特性而值得测试。

著录项

  • 作者

    Sindambiwe, Jean-Bosco.;

  • 作者单位

    Universitaire Instelling Antwerpen (Belgium).;

  • 授予单位 Universitaire Instelling Antwerpen (Belgium).;
  • 学科 Biology Microbiology.; Health Sciences Pharmacology.; Chemistry Pharmaceutical.
  • 学位 Ph.D.
  • 年度 1996
  • 页码 275 p.
  • 总页数 275
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 微生物学;药理学;药物化学;
  • 关键词

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