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In vitro studies on the cytotoxicity and adherence of Staphylococcus aureus to bovine mammary epithelial cells: Natural resistance mechanisms.

机译：金黄色葡萄球菌对牛乳腺上皮细胞的细胞毒性和粘附的体外研究：天然抗性机制。

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摘要

Bovine mammary secretory, ductal and teat epithelial cells, isolated at necropsy, were cultured in vitro and used as a model to study the cytotoxicity and mode of adherence of Staphylococcus aureus to mammary epithelium. Cells cultured on collagen formed confluent monolayers and were suitable for bacterial adherence studies.;Staphylococcus aureus adherence to epithelial cell monolayers was minimal compared to the adherence to subcellular matrix components. The adherence of S. aureus to the epithelial cells and the susceptibility of the epithelial cells to ;Casein in milk had an inhibitory effect on S. aureus cytotoxicity, but milk fat had no effect. Nonimmune serum from mature animals decreased toxin cell damage more effectively than serum from immature animals. Serum albumin had no effect. Concentrations of Ca;Antisera to ;These data contribute to a better understanding of the interaction between S. aureus and mammary epithelium needed for the development of immunization protocols to prevent S. aureus infection of the mammary gland.
机译：尸检时分离出的牛乳腺分泌，导管和乳头上皮细胞在体外培养，并用作研究金黄色葡萄球菌对乳腺上皮粘附的细胞毒性和模式的模型。在胶原蛋白上培养的细胞形成汇合的单层，适合细菌粘附研究。金黄色葡萄球菌对上皮细胞单层的粘附比对亚细胞基质成分的粘附少。金黄色葡萄球菌对上皮细胞的粘附和上皮细胞对酪蛋白的敏感性对牛奶中的金黄色葡萄球菌的细胞毒性有抑制作用，而乳脂则无作用。来自成熟动物的非免疫血清比未成熟动物的血清更有效地减少了毒素细胞的损害。血清白蛋白无作用。这些浓度的数据有助于更好地了解金黄色葡萄球菌与为预防金黄色葡萄球菌感染乳腺而制定的免疫方案所需的乳腺上皮之间的相互作用。

著录项

  • 作者

    Cifrian, Eduardo.;

  • 作者单位

    University of Maryland, College Park.;

  • 授予单位 University of Maryland, College Park.;
  • 学科 Biology Microbiology.;Biology Veterinary Science.
  • 学位 Ph.D.
  • 年度 1995
  • 页码 164 p.
  • 总页数 164
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

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