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Soft tissue attachment to implanted surfaces.

机译：软组织附着在植入表面上。

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摘要

The soft tissue attachment to natural teeth is composed of a specialized type of epithelium termed junctional epithelium together with a fibrous connective tissue attachment. Such an attachment is desirable at dental and percutaneous implants, but a true junctional epithelium has not been characterized at these sites. This study was undertaken to examine factors affecting soft tissue attachment to implanted surfaces. The hypotheses were that a connective tissue attachment is necessary to produce a stable epithelial attachment and prevent epithelial downgrowth, which may lead to exfoliation, but that such an epithelium may not have a phenotype identical to that of junctional epithelium. The present study utilized a model system in which Millipore filters with various surface modifications were implanted into the backskin of pigs or rats, subsequently removed and the nature of the soft tissue attachment examined.; When the effect of surface porosity of the filters was examined, it was found (Chapter IV) that a pore size of at least 3.0 micrometers was necessary for connective tissue attachment which inhibited the epithelial downgrowth that would otherwise result in exfoliation of the implant. This effect was evident as early as 10 days after implantation (Chapter V). Ingrowth of connective tissue into the porous implant stabilized the epithelium but did not promote an epithelium with the morphological characteristics of junctional epithelium. Treatment of the implant surface with cell attachment factors (Chapter VI) had a negligible effect on soft tissue attachment, although a titanium coating enhanced tissue adhesion. A biphasic implant (Chapter VII) was developed to provide a smooth surface for epithelial attachment and a porous surface for connective tissue attachment. Despite the formation of a stable tissue attachment, the epithelium differed from a "junctional" epithelium in not forming a basal lamina or hemidesmosomes. To examine the inductive influence of connective tissue, periodontal ligament fibroblasts were cultured on filters, which were then implanted (Chapter VIII). The resulting epithelium generally resembled junctional epithelium in morphology but lacked specialized attachment. This research offers basic information on the conditions necessary to promote a stable soft tissue attachment at the surface of dental or percutaneous implants.
机译：天然牙齿的软组织附着物是由特殊类型的上皮细胞（称为结缔上皮）和纤维结缔组织附着物组成。这种附着在牙科和经皮植入物上是理想的，但是在这些部位尚未鉴定出真正的接合上皮。进行这项研究以检查影响软组织附着于植入表面的因素。假设是结缔组织附着是产生稳定的上皮附着并防止上皮下垂的必要条件，这可能导致剥落，但这种上皮的表型可能与结节上皮的表型不同。本研究利用一种模型系统，将具有各种表面修饰的密理博滤器植入猪或大鼠的皮中，随后将其去除并检查软组织附着的性质。当检查过滤器的表面孔隙率的影响时，发现（第四章），结缔组织附着必须有至少3.0微米的孔径，这会抑制上皮下生长，否则会导致植入物脱落。早在植入后10天，这种效果就很明显（第五章）。结缔组织向多孔植入物中的生长稳定了上皮，但没有促进具有连接上皮形态特征的上皮。尽管钛涂层增强了组织附着力，但用细胞附着因子对植入物表面的处理（第六章）对软组织附着的影响可忽略不计。开发了一种双相植入物（第VII章）以提供上皮附着的光滑表面和结缔组织附着的多孔表面。尽管形成了稳定的组织附着，上皮与“结”上皮的不同之处在于不形成基底层或半桥粒。为了检查结缔组织的诱导作用，将牙周膜成纤维细胞培养在滤器上，然后将其植入（第八章）。所得的上皮在形态上通常类似于接合上皮，但缺乏专门的附着。这项研究提供了在牙科或经皮植入物表面促进稳定的软组织附着所需条件的基本信息。

著录项

  • 作者

    Romanowski, Ann Wegener.;

  • 作者单位

    The University of Iowa.;

  • 授予单位 The University of Iowa.;
  • 学科 Biology Anatomy.; Health Sciences Medicine and Surgery.; Health Sciences Dentistry.
  • 学位 Ph.D.
  • 年度 1994
  • 页码 188 p.
  • 总页数 188
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 生物形态学;口腔科学;
  • 关键词

  • 入库时间 2022-08-17 11:49:46

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