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The relationship between gastric mucosal acidosis and the development of sepsis and organ failure in the critically ill.

机译：危重病患者胃粘膜酸中毒与脓毒症和器官衰竭的发展之间的关系。

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摘要

Objective. To assess the relationship between the duration of gastric mucosal acidosis and the development of sepsis and multiple organ failure (MOF). Length of ICU stay, hospital stay, and hospital mortality were also recorded.;Design. Prospective comparison of outcome.;Setting. General adult ICU in a teaching hospital.;Patients. 48 consecutive critically ill patients with a predicted ICU stay ;Interventions. Gastric tonometers were placed in all patients and gastric intramucosal pH was measured at admission, 2 hrs, 4 hrs, 6 hrs, 12 hrs, 24 hrs, 36 hrs, and 48 hrs.;Main outcome measures. Organ system failure (OSF) scores, septic severity scores (SSS), length of hospital and ICU stays, and mortality were assessed.;Results. 26 of the 48 patients (54%) had mucosal acidosis at some point during the first 48 hours. Patients with gastric mucosal acidosis had higher OSF, SSS scores, and longer ICU stays compared to patients without acidosis. The duration of acidosis was strongly correlated with the OSF score and to the SSS. Patients with a longer duration of gastric mucosal acidosis were also more likely to die (p ;Conclusions. Critically ill patients with gastric mucosal acidosis are at increased risk for the development of sepsis and organ failure and tend to have longer ICU and hospital stays. Hospital mortality is increased in those patients with a longer duration of acidosis. Gastric tonometry is useful in predicting the development of MOF in critically ill patients. (Abstract shortened by UMI.).
机译：目的。评估胃粘膜酸中毒持续时间与脓毒症和多器官衰竭（MOF）的发展之间的关系。还记录了ICU的住院时间，住院时间和住院死亡率。结果的预期比较；设置。教学医院的普通成人加护病房。 48例重症患者，预计入住ICU；干预。在所有患者中放置胃压计，并在入院，2小时，4小时，6小时，12小时，24小时，36小时和48小时时测量胃粘膜内pH。评估器官系统衰竭（OSF）评分，败血症严重程度评分（SSS），住院时间和ICU住院时间以及死亡率。在48位患者中，有26位（54％）在最初的48小时内出现了粘膜酸中毒。与无酸中毒的患者相比，胃粘膜酸中毒的患者的OSF，SSS评分更高，ICU停留时间更长。酸中毒的持续时间与OSF评分和SSS密切相关。胃粘膜酸中毒持续时间较长的患者也更容易死亡（p；结论。患有胃粘膜酸中毒的危重病人患败血症和器官衰竭的风险增加，并且ICU和住院时间也更长。酸中毒持续时间较长的患者死亡率增加，胃压计可用于预测危重患者的MOF发生情况（UMI缩短）。

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  • 作者

    Just, Jon David.;

  • 作者单位

    University of Alberta (Canada).;

  • 授予单位 University of Alberta (Canada).;
  • 学科 Medicine.
  • 学位 M.Sc.
  • 年度 1994
  • 页码 83 p.
  • 总页数 83
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 老年病学;
  • 关键词

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