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Novel beta-lactam antibiotics: Study of their mode of action against beta-lactam recognizing enzymes.

机译：新型β-内酰胺类抗生素：研究其对抗β-内酰胺识别酶的作用方式。

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Since the pioneering work of du Vigneaud in the 1940s, conventional wisdom and practice assume that compounds derived from 6-D-aminopenicillanic acid (D-APA) and 7-aminocephalosporanic acid (7-ACA) should represent the most active forms. The new short four-step synthesis of ;Two analytical methods have been developed. The first is a method developed for the separation of L-APA zwitterionic diastereomers by anion-exchange chromatography. Four L-APA diastereomers can be separated with one of them being totally resolved. Hydrophobicity plays an important factor in this separation. The second is the development of a nonradioisotopic, fluorescent/spectroscopy in combination with chromatography based techniques for identification and quantification of the PBPs targets of these novel

机译：自从1940年代du Vigneaud的开创性工作以来，传统的常识和实践都假设衍生自6-D-氨基青霉酸（D-APA）和7-氨基头孢烷酸（7-ACA）的化合物是最活跃的形式。已开发出新的短四步合成法；两种分析方法。第一种是开发用于通过阴离子交换色谱分离L-APA两性离子非对映异构体的方法。可以分离四种L-APA非对映异构体，其中一种可以完全拆分。疏水性在这种分离中起重要作用。第二是非放射性同位素荧光/光谱学与基于色谱技术的结合，用于鉴定和定量这些新型PBPs靶标

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作者
Du, Ying.;
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作者单位

University of Cincinnati.;

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授予单位 University of Cincinnati.;
学科 Chemistry Analytical.;Chemistry Pharmaceutical.;Chemistry Biochemistry.
学位 Ph.D.
年度 1994
页码 264 p.
总页数 264
原文格式 PDF
正文语种 eng
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1. Combined effect of vancomycin or teicoplanin plus a beta-lactam antibiotic in mouse infection models caused by beta-lactam antibiotec-induced vancomycin resistant MRSA (BIVR) [J] . Hatano K, Yokota Y, Hanaki H, 感染症学雑誌 . 2006,第3期

机译：万古霉素或替考拉宁加β-内酰胺类抗生素在由β-内酰胺类抗生素引起的耐万古霉素MRSA（BIVR）引起的小鼠感染模型中的联合作用
2. Combined effect of vancomycin or teicoplanin plus a beta-lactam antibiotic in mouse infection models caused by beta-lactam antibiotec-induced vancomycin resistant MRSA (BIVR) [J] . Hatano K, Yokota Y, Hanaki H, 感染症学雑誌 . 2006,第3期

机译：Vancomycin或Teicoplanin加上β-内酰胺抗生素在β-内酰胺抗生素诱导的万古霉素抗性MRSA（BIVR）引起的小鼠感染模型中的β-内酰胺抗生素
3. OP0595, a new diazabicyclooctane: mode of action as a serine beta-lactamase inhibitor, antibiotic and beta-lactam 'enhancer' [J] . Morinaka Akihiro, Tsutsumi Yuko, Yamada Mototsugu, The Journal of Antimicrobial Chemotherapy . 2015,第10期

机译：OP0595，一种新的二氮杂双环辛烷：作用方式作为丝氨酸β-内酰胺酶抑制剂，抗生素和β-内酰胺'增强剂'
4. A Rapid Phenotypic Test for Beta-Lactam Antibiotic Susceptibility [C] . Eric Liaw International Molecular Medicine Tri-Conference. . 2019

机译：β-内酰胺抗生素敏感性的快速表型试验
5. The interaction of beta-lactams and beta-lactam binding enzymes: A computational study using molecular modeling, semi-empirical, and ab initio methods. [D] . Billings, Eric Michael. 1995

机译：β-内酰胺和β-内酰胺结合酶的相互作用：使用分子建模，半经验和从头算方法的计算研究。
6. Transition state structures of a dipeptide related to the mode of action of beta-lactam antibiotics. [O] . D B Boyd 1977

机译：二肽的过渡态结构与β-内酰胺类抗生素的作用方式有关。
7. Biosynthesis of Peptidoglycan in Pseudomonas aeruginosa. 2. Mode of Action of beta-Lactam Antibiotics [O] . David MIRELMAN, Yael NUCHAMOWITZ 1979

机译：Pseudomonas铜绿假单胞菌肽聚糖的生物合成。 2.β-内酰胺抗生素的作用方式

Novel beta-lactam antibiotics: Study of their mode of action against beta-lactam recognizing enzymes.

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