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Crocetin: A treatment of shock via enhanced oxygen transport.

机译：藏花红素：通过增强的氧气运输来治疗休克。

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摘要

Shock is a condition in which tissues are not sufficiently oxygenated (hypoxic), and it can result in death. In fact, it has been found that increasing oxygen consumption corresponds to an increased survival rate in shock. Thus, increasing oxygen consumption should be a useful therapy, and this was investigated using a rat model of hemorrhagic shock.;Some recent studies indicate that the rate of tissue oxygen consumption is controlled by the rate of diffusion of oxygen from the red blood cells to the mitochondria in certain cases. If this is also true for shock, increasing the diffusion of oxygen should have a beneficial effect. For example enhancing the diffusivity of oxygen through plasma might increase the flux of oxygen from blood cells to the mitochondria and reduce the risk of hypoxia. In vitro experiments show an increase of 25% in the diffusivity of oxygen through plasma when the carotenoid compound crocetin is added. Thus, crocetin was investigated as a treatment for hemorrhagic shock.;These experiments showed that there were significant increases in the oxygen consumption and survival of hemorrhaged rats treated with crocetin. Magnetic resonance spectroscopy of the gracilis muscle indicate that the metabolic energy levels return to normal in hemorrhaged animals treated with crocetin, a strong indication that sufficient oxygen supply to this tissue (and presumably others) has been restored. Magnetic resonance imaging experiments indicated that there was little, if any, effect of crocetin on blood flow in large vessels. Thus, it is suggested that crocetin aids in the restoration of normal oxygen supply to tissues after hemorrhagic shock, by increasing the diffusivity of oxygen, and increasing the chances of survival.
机译：休克是组织未充分充氧（缺氧）的一种状况，可能导致死亡。实际上，已经发现增加的氧气消耗量对应于休克的存活率增加。因此，增加耗氧量应该是一种有用的疗法，并且使用了失血性休克的大鼠模型对此进行了研究。；最近的一些研究表明，组织耗氧量受氧气从红血球扩散到红细胞的速率控制。线粒体在某些情况下。如果对于冲击也是如此，则增加氧气的扩散应具有有益的作用。例如，提高氧气通过血浆的扩散性可能会增加氧气从血细胞到线粒体的通量，并降低缺氧的风险。体外实验显示，添加类胡萝卜素大黄素时，氧在血浆中的扩散率提高了25％。因此，对番红花青素作为失血性休克的治疗方法进行了研究。这些实验表明，用番红花青素治​​疗的大白鼠的耗氧量和存活率均显着增加。束肌的磁共振波谱表明，在用藏红花酸处理的出血动物中，代谢能水平恢复正常，有力地表明已经恢复了对该组织（可能还有其他组织）的足够氧气供应。磁共振成像实验表明，番红花素对大血管的血流几乎没有影响。因此，建议大黄素通过增加氧气的扩散性和增加生存机会来帮助失血性休克后恢复正常的组织供氧。

著录项

  • 作者

    Rudolph, Daniel Brian.;

  • 作者单位

    University of Virginia.;

  • 授予单位 University of Virginia.;
  • 学科 Chemical engineering.;Biomedical engineering.
  • 学位 Ph.D.
  • 年度 1993
  • 页码 136 p.
  • 总页数 136
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

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