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首页> 外文学位 >Effects of hyperoxic exposure on the pulmonary eicosanoid profile and the relationship to the oxidant-induced lung pathology in neonatal rats.
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Effects of hyperoxic exposure on the pulmonary eicosanoid profile and the relationship to the oxidant-induced lung pathology in neonatal rats.

机译：高氧暴露对新生大鼠肺类二十烷酸谱的影响以及与氧化剂诱导的肺部病理的关系。

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摘要

he role of eicosanoids in the pathogenesis of Bronchopulmonary dysplasia was investigated by exposing neonatal rats to hyperoxia. A novel lung explant technique was developed to elucidate the in vivo pulmonary eicosanoid production during hyperoxic exposure.;The lung injury produced by the hyperoxic exposure protocol reflected the characteristic exudative, hypoplastic phase followed by a hyperplastic, fibrotic repair phase. In conjunction with this sequence of pulmonary injury, hyperoxia caused a progressive alteration in the capacity of the lung to produce the individual eicosanoids. It is speculated that the relative balance between the eicosanoids is an important determinant in the pathogenesis of pulmonary oxygen toxicity. (Abstract shortened by UMI.).;Following 7 days of hyperoxia, basal and stimulated outputs of the 3 eicosanoids measured were elevated (p
机译：通过将新生大鼠暴露于高氧状态，研究了类花生酸在支气管肺发育不良的发病机理中的作用。开发了一种新的肺外植体技术，以阐明高氧暴露过程中体内肺类二十烷酸的产生。;高氧暴露方案产生的肺损伤反映出特征性的渗出性增生期，然后是增生性纤维化修复期。与一系列的肺损伤相结合，高氧引起肺产生单个类花生酸的能力的逐步改变。据推测，类花生酸之间的相对平衡是决定肺氧中毒的重要因素。 （摘要由UMI缩短。）；在高氧持续7天后，测得的3种类花生酸的基础和刺激输出增加（p

著录项

  • 作者

    Koyanagi, Kim Shigeko.;

  • 作者单位

    University of Alberta (Canada).;

  • 授予单位 University of Alberta (Canada).;
  • 学科 Animal Physiology.
  • 学位 M.Sc.
  • 年度 1993
  • 页码 262 p.
  • 总页数 262
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 老年病学;
  • 关键词

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