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首页> 外文学位 >Glutathione, glutathione S-transferases activity and immune responses in chickens following exposure to vitamin A during development and fed excess vitamin E.
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Glutathione, glutathione S-transferases activity and immune responses in chickens following exposure to vitamin A during development and fed excess vitamin E.

机译：鸡在发育过程中暴露于维生素A并饲喂过量的维生素E后，谷胱甘肽，谷胱甘肽S转移酶活性和免疫反应。

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摘要

The objectives of the experiments were to explore the possibility of utilizing the nutrients, vitamins A and E, during embryogenesis or post-hatching to influence glutathione S-transferase (GST) activity and glutathione (GSH) concentration, and consequently influence growth and immune responses in chickens.; The developments of hepatic GST activity and GSH concentration during embryogenesis and post-hatching were examined. Hepatic GST activity gradually decreased during embryogenesis. However, hepatic GST activity significantly increased in the first six days of the post-hatching period. The pattern of hepatic GSH concentration during embryogenesis and post-hatching period was very similar to the developmental changes in hepatic GST activity.; The relationship between hepatic GST activity and GSH concentration was determined by the method of fasting. Fasting decreased both hepatic GST activity and GSH concentration. It also confirmed the finding of the previous study that a strong relationship existed between hepatic GST activity and GSH concentration.; When hatching eggs were dipped in retinol acetate solution on day 2 or 4 of the incubation period, hatchability was not affected. Production of IgM and IgG and delayed hypersensitivity response (DHR), an indicator of cell-mediated immunity in bird, were not affected. However, exposure of the developing embryo to retinoic acid solutions (10, 100 1000 ng/egg) on day 4 or 11 of the incubation period, severely depressed hatchability. These levels of retinoic acid did not affect the growth of birds post-hatching. Humoral immunity was increased while cell-mediated immunity was depressed by the toxic doses of retinoic acid.; The effect of vitamin E on body weight, GST activity, GSH concentration and the immune response in birds was evaluated. Feeding birds with 300 mg vitamin E/kg did not change body weight, GST activity and GSH concentration in different organs, humoral immunity and DHR.; The combination of vitamins A and E on hatchability and the above parameters was studied. Hatchability and body weight were not affected by dipping hatching eggs in retinoic acid solution (10 ng/egg). However, subsequent decreased humoral immunity and enhanced cell-mediated immunity in birds demonstrated that retinoic acid did affect the development of embryo during embryogenesis. Excess vitamin E increased humoral immunity but cell-mediated immunity was not affected.
机译：实验的目的是探索在胚胎发生或孵化后利用营养素，维生素A和E来影响谷胱甘肽S-转移酶（GST）活性和谷胱甘肽（GSH）浓度，从而影响生长和免疫反应的可能性。在鸡里。研究了胚胎发生和孵化后肝脏GST活性和GSH浓度的变化。肝GST活性在胚胎发生过程中逐渐降低。但是，在孵化期后的前六天，肝脏GST活性显着增加。胚胎发生和孵化后肝脏GSH浓度的变化模式与肝脏GST活性的发育变化非常相似。通过禁食的方法确定肝GST活性与GSH浓度之间的关系。空腹降低肝GST活性和GSH浓度。这也证实了先前研究的发现，即肝脏GST活性与GSH浓度之间存在密切关系。在孵化期的第2天或第4天将孵化蛋浸入醋酸视黄醇溶液中时，孵化率不会受到影响。 IgM和IgG的产生以及迟发性超敏反应（DHR）（禽类中细胞介导的免疫反应的指标）不受影响。但是，在孵化期的第4天或第11天，将发育中的胚胎暴露于视黄酸溶液（10、100 1000 ng / egg）中，会严重降低孵化率。这些视黄酸水平并不影响孵化后的家禽生长。体液免疫剂量因视黄酸的毒性剂量而降低。评估了维生素E对鸟类体重，GST活性，GSH浓度和免疫反应的影响。饲喂300 mg维生素E / kg的家禽不会改变体重，不同器官的GST活性和GSH浓度，体液免疫力和DHR。研究了维生素A和E对孵化率的影响以及上述参数。将孵化蛋浸入视黄酸溶液（10 ng /蛋）中不会影响孵化率和体重。但是，随后降低的禽体液免疫力和增强的细胞介导免疫力表明，视黄酸确实会影响胚胎发生过程中胚胎的发育。过量的维生素E增强了体液免疫，但细胞介导的免疫并未受到影响。

著录项

  • 作者

    Hsu, Kuo-Tung.;

  • 作者单位

    Clemson University.;

  • 授予单位 Clemson University.;
  • 学科 Agriculture Animal Culture and Nutrition.
  • 学位 Ph.D.
  • 年度 1992
  • 页码 108 p.
  • 总页数 108
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 饲料;
  • 关键词

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