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Investigating the effects of ancestral stress, environmental enrichment and the concept of allostatic load.

机译:研究祖先压力,环境富集和恒力负荷的影响。

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摘要

The stress that our ancestors experienced resonates with us in their stories, and memoires, but does it affect our health? In this thesis, the impact of ancestral stress on offspring was investigated. We hypothesized that ancestral stress has a significant impact on the development of the stress response, neuromorphology, and behaviour. Moreover, as stress is multi-systematic in its effects, this study examined the use of a new stratification tool termed the cumulative animal allostatic load index (CAALM). In addition, we tested the influence of postnatal enriched environment (EE) on ancestral stress-induced deficits. Lastly, we investigated a "two-hit hypothesis" of maternal stress and inflammation on offspring development. Overall, results indicate that ancestral stress is transferred across generations and increases allostatic load, and EE reverses detrimental effects. Moreover, inflammation exacerbates the effect of stress. Altogether, our results shed light on the influence of maternal and ancestral health on offspring development and the benefit of EE.
机译:我们的祖先所经历的压力在他们的故事和回忆录中与我们产生共鸣,但这会影响我们的健康吗?本文研究了祖先应激对后代的影响。我们假设祖先应激对应激反应,神经形态学和行为的发展有重要影响。此外,由于压力的影响是多系统的,因此本研究检查了一种新的分层工具的使用,该工具称为累积动物同化负荷指数(CAALM)。此外,我们测试了产后丰富环境(EE)对祖先应激诱发的缺陷的影响。最后,我们研究了母体压力和炎症对后代发育的“两次打击假说”。总体而言,结果表明祖先应力跨代转移,并增加了静力负荷,而EE逆转了有害影响。此外,炎症加剧了压力的作用。总之,我们的结果揭示了母体和祖传健康对后代发育的影响以及EE的益处。

著录项

  • 作者

    McCreary, J. Keiko.;

  • 作者单位

    University of Lethbridge (Canada).;

  • 授予单位 University of Lethbridge (Canada).;
  • 学科 Neurosciences.;Developmental biology.
  • 学位 Ph.D.
  • 年度 2016
  • 页码 200 p.
  • 总页数 200
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

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