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Longitudinal changes in bone mineral density in patients following total hip replacement

机译：全髋关节置换术后患者骨矿物质密度的纵向变化

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摘要

This thesis presents data on a one-year study of the relative effects of total hip replacement surgery on the bone mineral density (BMD) in ten osteoarthritic patients (three males + seven females), aged 49 to 81 years.;Bone mineral density (BMD) in the lumbar spine (L$sb1$ to L$sb4$), and in the proximal femur (neck, trochanter, intertrochanteric region, and Ward's triangle) was measured using dual energy x-ray absorptiometry (DEXA). BMD measurements were made for each subject at baseline (one month before surgery), and at 4 and 12 months after surgery.;Bone biopsies from the intertrochanteric region of the femur were obtained intraoperatively and processed for the evaluation of histomorphometric variables. Biochemical data collected at baseline included: 25-hydroxy vitamin D, parathyroid hormone, total proteins, serum ionized calcium, and serum alkaline phosphatase.;At baseline, BMD measurements and bone histomorphometric variables did not show a significant correlation, but a strong correlation was observed between BMD measurements and biochemical data.;For all subjects, BMD in the spine and proximal femur at 4 and 12 months were not significantly different from baseline. In 4 of 10 patients, however, BMD in the spine was significantly different between baseline and 4-months, and also between 4-months and 12-months.;These data suggest that the new biomechanical status following total hip replacement may have a positive effect on BMD in the lumbar spine.
机译：本论文提供了一项为期一年的研究数据，研究了10例年龄在49至81岁的骨关节炎患者中全髋关节置换术对骨矿物质密度（BMD）的相对影响。使用双能X线骨密度仪（DEXA）测量了腰椎（L $ sb1 $至L $ sb4 $）和股骨近端（颈部，转子，转子间区域和沃德三角形）的BMD。在基线时（手术前一个月）以及手术后4个月和12个月对每位受试者进行BMD测量。术中获取股骨转子间区域的骨活检并进行处理，以评估组织形态计量学变量。在基线时收集的生化数据包括：25-羟基维生素D，甲状旁腺激素，总蛋白，血清离子钙和血清碱性磷酸酶。在基线时，BMD测量值和骨组织形态计量学变量未显示出显着的相关性，但相关性很强。在所有BMD测量值和生化数据之间观察到；在所有受试者中，第4和12个月时脊柱和股骨近端的BMD与基线无显着差异。然而，在10位患者中有4位的基线和4个月之间以及4个月和12个月之间，脊柱BMD均存在显着差异;这些数据表明，全髋关节置换术后新的生物力学状态可能呈阳性对腰椎骨密度的影响。

著录项

  • 作者

    Girgis, Safwat.;

  • 作者单位

    University of Alberta (Canada).;

  • 授予单位 University of Alberta (Canada).;
  • 学科 Medicine.
  • 学位 M.Sc.
  • 年度 1991
  • 页码 129 p.
  • 总页数 129
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 老年病学;
  • 关键词

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