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首页> 外文学位 >THE METABOLIC FATE OF TRITIUM-LABELED T-2 TOXIN, A TRICHOTHECENE MYCOTOXIN, IN SWINE.
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THE METABOLIC FATE OF TRITIUM-LABELED T-2 TOXIN, A TRICHOTHECENE MYCOTOXIN, IN SWINE.

机译：猪中。标记的T-2毒素（一种trichothecene霉菌毒素）的代谢命运。

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摘要

The metabolic fate of T-2 toxin was determined in two female crossbred swine following the intravascular administration of one millicurie of tritium-labeled T-2 toxin at a nonlethal dose of 0.15 mg/kg body weight. The plasma elimination phase half-life was 90 minutes for total tritium residues. A total of 13.1 and 1.3 percent of the administered dose was found in the gall bladders in addition to 17.9 and 42.5 percent in the urine of the two pigs, S1 and S2, respectively, 4 hours after dosing. Free metabolites, identified by thin-layer chromatography, represented less than 20 and 30 percent of the metabolite residues in bile and urine, respectively, with the parent compound, T-2 toxin, never exceeding 0.25 percent. The major free metabolites were 3'-OH HT-2 and T-2 triol. Glucuronide conjugates represented 63 and 77 percent of the metabolite residues in urine and bile, respectively. The major conjugated metabolites were glucuronides of HT-2, 3'-OH T-2, 3'-OH HT-2 and T-2 toxin. Neosolaniol, 4-deacetyl-neosolaniol and T-2 tetraol were also identified in addition to 3 unknown metabolites.;In the tissues, the greatest amount of radioactivity was located in the gastrointestinal tract (15.5 and 24.1 percent of the dose for the 2 pigs, S1 and S2, respectively). The remaining tissues sampled accounted for approximately 5 percent of the dose for the 2 pigs. Twenty-one metabolites were identified in tissues following reverse phase HPLC radiochromatography. Approximately 55 percent of the extractable radioactivity in the tissues, including the gastrointestinal tract, of both pigs corresponded to T-2 toxin, HT-2, deepoxy HT-2, T-2 triol, deepoxy T-2 triol, 3'-OH T-2, 3'-OH HT-2, T-2 tetraol and deepoxy T-2 tetraol. The major metabolite in tissues, PM-XV, did not correspond to any standard and represented an additional 27 percent of the extractable radioactivity.
机译：在以0.15 mg / kg体重的非致死剂量向血管内注射一毫uri标记的T-2毒素后，在两只雌性杂交猪中确定了T-2毒素的代谢命运。对于总tri残留物，等离子体消除相的半衰期为90分钟。给药后4小时，在两只猪S1和S2的尿液中，分别在胆囊中发现了总剂量的13.1％和1.3％，在尿液中分别发现了17.9％和42.5％。通过薄层色谱法鉴定的游离代谢物，在胆汁和尿液中分别占不到20％和30％的代谢物残基，而母体化合物T-2毒素从未超过0.25％。主要的游离代谢产物是3'-OH HT-2和T-2三醇。葡萄糖醛酸结合物分别占尿液和胆汁中63％和77％的代谢物残基。主要的共轭代谢产物是HT-2、3'-OH T-2、3'-OH HT-2和T-2毒素的葡萄糖醛酸。除了3种未知的代谢物外，还鉴定出新松香酚，4-脱乙酰基新松香酚和T-2四醇;在组织中，最大的放射性位于胃肠道（2头猪的剂量分别占剂量的15.5％和24.1％） ，分别为S1和S2）。剩余的组织样本约占2头猪剂量的5％。反相HPLC放射色谱法后在组织中鉴定出21种代谢物。两只猪的包括胃肠道在内的组织中大约55％的可提取放射性对应于T-2毒素，HT-2，深氧HT-2，T-2三醇，深氧T-2三醇，3'-OH T-2、3'-OH HT-2，T-2四元醇和Deepoxy T-2四元醇。组织中的主要代谢物PM-XV不符合任何标准，并且占可提取放射性的27％。

著录项

  • 作者

    CORLEY, RICHARD ALLEN.;

  • 作者单位

    University of Illinois at Urbana-Champaign.;

  • 授予单位 University of Illinois at Urbana-Champaign.;
  • 学科 Physics Nuclear.
  • 学位 Ph.D.
  • 年度 1985
  • 页码 131 p.
  • 总页数 131
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 原子核物理学、高能物理学;
  • 关键词

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