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Meniscus-directed assembly of biologically active coatings of cells, microparticles, and nanoparticles.

机译：细胞，微粒和纳米粒子的生物活性涂层的弯月面导向组装。

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Convective assembly principles and techniques were used in two complementary studies for depositing close packed yeast-coated surfaces and gold nanoparticle wires. Convective assembly at high volume fraction was used for the rapid deposition of uniform, close-packed coatings of Saccharomyces cerevisiae onto glass slides. A computational model was developed to calculate the thickness profiles of such coatings for various experimental conditions. Both experimentation and numerical simulations demonstrated that the deposition process is strongly affected by the presence of sedimentation. The deposition device was inclined to increase the uniformity of the coatings by causing the cells to sediment toward the three-phase contact line. In accordance with the simulation, the experiments showed that both increasing the angle of the device and decreasing the angle between the slides increased the uniformity of the deposited coatings. Finally, the "convective-sedimentation" assembly method was used to deposit composite coatings of live cells and large latex particles as an example of biologically active composite coatings. These coatings were allowed to proliferate and demonstrate a proof-of-concept of a self-cleaning surface.;Two methods were developed for the deposition of micro- and nanoparticles into linear assemblies that could be used in biosensors and biomaterials. In capillary-guided deposition, a capillary is withdrawn across a wettable substrate, resulting in the assembly of a particle line. We characterized the effects of particle concentration and withdrawal speed and correlated them to structure of the deposited assemblies. The particles are assembled into one of three different structures, depending on the particle volume fraction and deposition speed. We demonstrate that the metallic nanoparticle lines are Ohmically conductive. Using wedge-templated deposition, linear assemblies were deposited from sessile droplets on moderately hydrophobic surfaces. The particles convectively assemble at the freely-receding three-phase contact line and are pulled into a line against the wedge. The deposited lines can be long and narrow with a few breaks or significantly wider and shorter but unbroken. These methods could be used for engineered patterning of nanoparticle structures on surfaces.
机译：对流组装原理和技术被用于两项互补研究中，以沉积紧密堆积的酵母涂层表面和金纳米粒子丝。高体积分数的对流组件用于将酿酒酵母的均匀，密堆积的涂层快速沉积在载玻片上。开发了用于在各种实验条件下计算这种涂层的厚度分布的计算模型。实验和数值模拟均表明，沉积过程对沉积过程的影响很大。沉积装置倾向于通过使细胞向三相接触线沉积而增加涂层的均匀性。根据模拟，实验表明，增加装置的角度和减小载玻片之间的角度都可以增加沉积涂层的均匀性。最后，“对流沉降”组装方法被用来沉积活细胞和大胶乳颗粒的复合涂层，作为生物活性复合涂层的一个例子。这些涂层被允许扩散并显示出自清洁表面的概念证明。研发了两种方法，可将微米级和纳米级颗粒沉积到线性组件中，该组件可用于生物传感器和生物材料。在毛细管引导的沉积中，将毛细管从可湿性基材上抽出，从而形成颗粒线的组合。我们表征了颗粒浓度和撤离速度的影响，并将它们与沉积组件的结构相关联。取决于颗粒体积分数和沉积速度，将颗粒组装成三种不同结构之一。我们证明金属纳米粒子线是欧姆导电的。使用楔形模板沉积，线性组件从无数小滴沉积在中等疏水性表面上。颗粒在自由进入的三相接触线处对流地聚集，并被拉向楔形线。沉积的线可以是长而窄的，具有一些中断，也可以是宽而短但不间断的。这些方法可用于在表面上对纳米颗粒结构进行工程化构图。

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