• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文学位 >Gout: Risk factors for recurrent attacks and risk of adverse cardiovascular outcomes.
【24h】

Gout: Risk factors for recurrent attacks and risk of adverse cardiovascular outcomes.

机译：痛风：反复发作的危险因素和不良心血管结果的风险。

获取原文
获取原文并翻译 | 示例
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Gout, the most common crystal-induced arthritis, is characterized by recurrent attacks. Gout and hyperuricemia, which leads to gout, have been linked to adverse cardiovascular events, but the biological mechanism is not clear. An understanding of gout's relation to cardiovascular outcomes and triggers for recurrent attacks are becoming an issue of greater public health importance given the rising prevalence of the disease. The following hypotheses were evaluated: (1) The quantity (including light-tomoderate amounts) and type of alcoholic beverage intake are associated with increased risk of recurrent gout attacks; (2) Weather-related factors are associated with increased risk of recurrent gout attacks; and (3) Hyperuricemia is associated with increased prevalence of carotid plaques but not coronary artery calcification, two markers of cardiovascular disease reflecting different pathologic features.;To address the first two hypotheses, 349 participants from an internet-based case-crossover study of individuals with gout were studied. In the first study, 1 to 2 servings of alcohol in the prior 24 hours, compared with no alcohol intake, were associated with a 40% (95% CI 0.88-2.33) increased risk of gout attack. All types of alcoholic beverages were associated with an increased risk of recurrent attacks.;In the second study, hot weather (≥80°F) and high humidity in the prior 24 hours, compared with moderate temperatures and normal humidity, respectively, were associated with increased risk for gout attacks (relative risk 1.64 (95% CI 1.02-2.64) and 1.30 (95% CI 1.06-1.60), respectively).;The third hypothesis was addressed using data from the National Heart, Blood, and Lung Institute (NHLBI) Family Heart Study. The adjusted risk of having prevalent carotid plaques was 1.75 times higher among males with SUA ≥6.8mg/dL than in those with the lowest levels of SUA (95% CI 1.21-2.51). For coronary artery calcification, the adjusted risk that was 1.06 times higher among males with the highest levels of SUA compared with the lowest levels (95% CI 0.70-1.59).;These studies provide insight into specific factors that trigger recurrent gout attacks, which may aid in making clinical recommendations to persons with gout, and into potential biological mechanisms through which uric acid may increase the risk of adverse cardiovascular disease.
机译：痛风是最常见的晶体诱发的关节炎，其特征是反复发作。导致痛风的痛风和高尿酸血症与不良心血管事件有关，但生物学机制尚不清楚。鉴于痛风与心血管疾病的关系以及反复发作的诱因，对这种疾病的认识正变得越来越重要，这是由于该疾病的患病率越来越高。对以下假设进行了评估：（1）酒精饮料的摄入量（包括轻至中度的摄入量）和类型与复发性痛风发作的风险增加相关； （2）与天气有关的因素与痛风复发的风险增加有关； （3）高尿酸血症与颈动脉斑块患病率升高相关，但与冠状动脉钙化无关，这是反映不同病理特征的心血管疾病的两个标志。；为解决前两个假设，来自基于互联网的个体案例研究的349名参与者与痛风进行了研究。在第一项研究中，与未饮酒相比，前24小时饮酒1-2次与痛风发作风险增加40％（95％CI 0.88-2.33）有关。所有类型的酒精饮料都与反复发作的风险增加有关。在第二项研究中，与之前的中温和正常湿度相比，之前24小时的炎热天气（≥80°F）和高湿度相关痛风发作的风险增加（相对风险分别为1.64（95％CI 1.02-2.64）和1.30（95％CI 1.06-1.60））.;第三个假设是使用美国国家心脏，血液和肺部研究所的数据（NHLBI）家庭心脏研究。 SUA≥6.8mg/ dL的男性经调整的患颈总动脉斑块的风险比最低水平的SUA（95％CI 1.21-2.51）高1.75倍。对于冠状动脉钙化，SUA水平最高的男性与最低水平的男性（95％CI 0.70-1.59）相比，调整后的风险高1.06倍。这些研究为引发痛风复发的特定因素提供了见识，可能有助于向痛风患者提供临床建议，并有助于潜在的生物学机制，尿酸可能通过这种机制增加不良心血管疾病的风险。

著录项

  • 作者

    Neogi, Tuhina.;

  • 作者单位

    Boston University.;

  • 授予单位 Boston University.;
  • 学科 Health Sciences Medicine and Surgery.;Health Sciences Public Health.
  • 学位 Ph.D.
  • 年度 2009
  • 页码 124 p.
  • 总页数 124
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 预防医学、卫生学;
  • 关键词

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号