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Does genotype moderate the effects of concussion history and contact exposure on working memory processes in retired football players?

机译：基因型是否减轻了退役足球运动员的脑震荡史和接触暴露对工作记忆过程的影响？

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摘要

Recent studies have linked concussions earlier in life and later memory problems, but little is known about neurocognitive long-term effects of concussion, and whether a genetic risk factor for Alzheimer's Disease, Apolipoprotein-e4 (APOE-e4), might play a role in these long-term effects. In the present study, participants between 50-65 (N=63) were grouped based on concussion history (0-1 or 3+), football exposure (college or college+NFL), and APOE-e4 status (APOE-e4+ or APOE-e4-). Participants completed two batteries of neurocognitive tasks, and performed an fMRI-adapted N-back task. Neurocognitive results revealed selective deficits in memory across all sub-groups, but no differences between the groups. Functional connectivity results suggested that APOE-e4 genotype interacted with concussion and exposure history in accounting for differences in connectivity within a fronto-parietal working memory network. Thus, while there are no behavioral differences between groups, functional connectivity may be altered by the interaction between concussion history, football exposure, and APOE-e4 status.
机译：最近的研究已将脑震荡联系到生命的早期和后期的记忆问题，但对脑震荡的神经认知长期影响以及阿尔茨海默氏病的遗传危险因素载脂蛋白-e4（APOE-e4）是否可能在脑震荡中发挥作用知之甚少这些长期影响。在本研究中，根据脑震荡史（0-1或3+），足球暴露（学院或大学+ NFL）和APOE-e4状态（APOE-e4 +或APOE-e4-）。参与者完成了两连串的神经认知任务，并执行了适应fMRI的N背任务。神经认知的结果显示，所有亚组的记忆选择性缺陷，但各组之间没有差异。功能连通性结果表明，APOE-e4基因型与脑震荡和暴露史相互作用，从而解释了额顶工作记忆网络内的连通性差异。因此，尽管各组之间在行为上没有差异，但脑震荡史，足球暴露和APOE-e4状态之间的相互作用可能会改变功能连接性。

著录项

  • 作者

    Varangis, Eleanna Martha Lyman.;

  • 作者单位

    The University of North Carolina at Chapel Hill.;

  • 授予单位 The University of North Carolina at Chapel Hill.;
  • 学科 Cognitive psychology.;Neurosciences.;Aging.
  • 学位 M.A.
  • 年度 2015
  • 页码 86 p.
  • 总页数 86
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

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