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首页> 外文学位 >Safety evaluation of permethrin and indoxacarb in dogs topically exposed to ActivylRTM tick plus.
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Safety evaluation of permethrin and indoxacarb in dogs topically exposed to ActivylRTM tick plus.

机译：苄氯菊酯和茚虫威在局部暴露于ActivylRTM tick plus的狗中的安全性评估。

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摘要

The use of ectoparasiticides on pets is incredibly important since pets are commonly infested with fleas, ticks, and other external parasites. Unfortunately, there is very little data on the safety of these products for dogs, their owners, and veterinary personnel who come into contact with the animals on a daily basis. Therefore, this investigation was undertaken to determine the residue of permethrin and indoxacarb in the dog's blood and to determine the transferable residues of these insecticides to gloves worn while petting six adult dogs after the topical application of Activyl RTM Tick Plus. Samples were collected on days 0, 1, 2, 3, 7, 14, 21, 28, and 35. At these time intervals, the dogs also underwent physical examination. The blood samples (approximately 4-5 ml) were collected into EDTA tubes. The glove samples were obtained by using 100% cotton gloves and petting each dog for 5 minutes, using a new glove each time. Blood and glove samples were extracted in methylene chloride:petroleum ether (1:1), and the extracts were assayed for residues of permethrin and indoxacarb using GC/MS. Blood analysis did not reveal the presence of permethrin or indoxacarb at any time during the investigation. In the gloves, the highest concentrations of permethrin and indoxacarb were determined at 24 hr (819.80 +/- 253.22; 90.80 +/- 35.16 mug/g, respectively). Residues of both compounds were found in significant concentrations in the gloves until day 7 (174.85 +/- 46.98; 7.63 +/- 2.83 mug/g, respectively). Permethrin residue was found in the gloves in detectable amounts until day 35 (28.12 +/- 11.59 mug/g). Indoxacarb residue was found in the gloves in insignificant amounts until day 21 (0.65 +/- 0.45 mug/g). In conclusion, ActivylRTM Tick Plus appears to be safe for dogs, as no adverse reactions occurred and residue was never found in the blood. Owners and veterinary personnel can be exposed to significant levels of permethrin and indoxacarb following daily exposure if proper precautions are not taken.
机译：由于宠物通常会感染跳蚤，壁虱和其他外部寄生虫，因此在宠物上使用除草剂非常重要。不幸的是，很少有关于这些产品对每天与动物接触的狗，狗的主人和兽医人员的安全性的数据。因此，进行了这项研究，以确定狗血中的苄氯菊酯和茚虫威的残留量，并确定在局部施用Activyl RTM Tick Plus后，抚摸六只成年犬时戴在手套上的这些杀虫剂的可转移残留物。在第0、1、2、3、7、14、21、28和35天收集样品。在这些时间间隔，对狗也进行身体检查。将血液样品（约4-5毫升）收集到EDTA管中。手套样品是通过使用100％棉手套并抚摸每只狗5分钟，每次使用新手套来获得的。在二氯甲烷：石油醚（1：1）中提取血液和手套样品，并使用GC / MS对提取液中的苄氯菊酯和茚虫威残留进行检测。血液分析未在调查过程中的任何时间显示出氯菊酯或茚虫威的存在。在手套中，苄氯菊酯和茚虫威的最高浓度确定为24小时（分别为819.80 +/- 253.22； 90.80 +/- 35.16杯/克）。直到第7天，这两种化合物的残留物在手套中的浓度都很高（分别为174.85 +/- 46.98； 7.63 +/- 2.83马克杯/克）。直到第35天，手套中的苄氯菊酯残留量仍可检测到（28.12 +/- 11.59马克杯/克）。到第21天，手套中发现的茚虫威残留量很小（0.65 +/- 0.45杯/克）。总而言之，ActivylRTM Tick Plus似乎对狗是安全的，因为没有发生不良反应，并且从未在血液中发现残留物。如果未采取适当的预防措施，则每日接触后的所有者和兽医人员可能会接触大量的苄氯菊酯和茚虫威。

著录项

  • 作者

    Litchfield, Hailey E.;

  • 作者单位

    Murray State University.;

  • 授予单位 Murray State University.;
  • 学科 Agriculture.;Veterinary science.;Animal sciences.
  • 学位 M.S.
  • 年度 2015
  • 页码 68 p.
  • 总页数 68
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

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