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Preparation and characterization of multi-layer biodegradable nanofibers by coaxial electrospinning and their potential for tissue engineering.

机译：同轴电纺多层可降解纳米纤维的制备与表征及其在组织工程中的潜力。

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摘要

As an evolution of conventional electrospinning, coaxial electrospinning became popular soon after its debut as a novel way to develop nanofibers with special structures, such as core-shell and hollow interior. In recent years, there has been an increasing interest in a modified coaxial electrospinning, tri-layer coaxial electrospinning, to develop more complex structures, such as multi-layer and nanowire-in-microtube. Previous studies have primarily concentrated on the fabrication of tri-layered inorganic fibers while studies on tri-layered coaxial polymeric fibers has not been reported until very recently. Our research focuses on the fabrication of core-shell and tri-layer structured biodegradable polymeric nanofibers with coaxial electrospinning. Different characterization methods have been applied to observe the internal structure in single nanofibers and the potential application of tri-layer coaxial electrospinning has been discussed.;The material system consists of biodegradable natural polymer gelatin, synthetic polymers poly (epsilon-caprolactone) (PCL) and poly (lactic-co-glycolic acid) (PLGA). A uniquely designed three-needle concentric spinneret is developed to perform tri-layer coaxial electrospinning. Different kinds of core-shell structured nanofibers, including gelatin/PCL, PCL/gelatin, gelatin/PLGA and PCL/PLGA, have been fabricated with a customized coaxial electrospinning apparatus. Two kinds of tri-layer coaxial nanofibers, two-component ABA structured gelatin/PCL/gelatin biodegradable nanofibers and tri-component ABC structured gelatin/PCL/PLGA biodegradable nanofibers, have been developed with the customized three needle coaxial electrospinning setup.;The core-shell and tri-layered structures of electrospun nanofibers have been characterized by several commonly used techniques, such as laser scanning confocal microscopy (LSCM) and transmission electron microscopy (TEM). Besides the conventional methods, other newer techniques, including focused ion beam-scanning electron microscopy (FIB-SEM), super-resolution structured illumination microscopy (SR-SIM) and nanoscale-infrared spectroscopy (nano-IR), have been explored to investigate the internal structure in singles fibers.;Additionally, the potential application of coaxial electrospinning in the fabrication of bioactive scaffolds for tissue engineering has been studied. Different kinds of coaxial nanofibers were fabricated and studied to determine the potential for BSA and growth factor release and some preliminary results were obtained.
机译：随着传统静电纺丝技术的发展，同轴静电纺丝技术在其首次亮相后不久就开始流行，它是一种开发具有特殊结构（例如核-壳和中空内部结构）的纳米纤维的新颖方法。近年来，人们对改进的同轴电纺，三层同轴电纺越来越感兴趣，以开发更复杂的结构，例如多层微管和纳米线。先前的研究主要集中在三层无机纤维的制造上，而直到最近才报道过对三层同轴聚合物纤维的研究。我们的研究重点是通过同轴静电纺丝技术制造核壳和三层结构的可生物降解聚合物纳米纤维。已采用不同的表征方法观察单纳米纤维的内部结构，并讨论了三层同轴电纺丝的潜在应用。；材料体系由可生物降解的天然聚合物明胶，合成聚合物聚（ε-己内酯）（PCL）组成和聚乳酸-乙醇酸共聚物（PLGA）。开发了独特设计的三针同心喷丝头，以执行三层同轴静电纺丝。已经使用定制的同轴电纺丝设备制造了包括明胶/ PCL，PCL /明胶，明胶/ PLGA和PCL / PLGA在内的不同种类的核-壳结构纳米纤维。通过定制的三针同轴电纺丝装置，已经开发出两种三层同轴纳米纤维，即两组分ABA结构的明胶/ PCL /明胶可生物降解的纳米纤维和三组分ABC结构的明胶/ PCL / PLGA可生物降解的纳米纤维。电纺纳米纤维的壳状和三层结构已通过几种常用技术进行了表征，例如激光扫描共聚焦显微镜（LSCM）和透射电子显微镜（TEM）。除了传统方法外，还探索了其他更新技术，包括聚焦离子束扫描电子显微镜（FIB-SEM），超分辨率结构照明显微镜（SR-SIM）和纳米红外光谱（nano-IR）。此外，研究了同轴电纺在组织工程生物活性支架制造中的潜在应用。制备并研究了不同种类的同轴纳米纤维，以确定其潜在的牛血清白蛋白和生长因子的释放，并获得了一些初步结果。

著录项

  • 作者

    Liu, Wenwen.;

  • 作者单位

    University of Delaware.;

  • 授予单位 University of Delaware.;
  • 学科 Materials science.;Nanotechnology.
  • 学位 Ph.D.
  • 年度 2015
  • 页码 146 p.
  • 总页数 146
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

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