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首页> 外文学位 >High Resolution Cardiac Magnetic Resonance Elastography: From Phantom to Mouse Heart.
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High Resolution Cardiac Magnetic Resonance Elastography: From Phantom to Mouse Heart.

机译：高分辨率心脏磁共振弹性成像：从幻影到小鼠心脏。

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摘要

First proposed in 1995, magnetic resonance elastography (MRE) has attracted more and more attention with its capability of estimating soft tissue stiffness non-invasively. In addition to the FDA-certified application for hepatic disease diagnosis, MRE has been studied in multiple organs as a potential new biomarker in various disease diagnoses, especially in recent years. Beside the application to disease diagnosis, MRE has also been utilized in monitoring the development of engineered tissue and in more fundamental studies of tissue viscoelasticity.;This dissertation aims to advance the application of high field MRE on complex anatomical structures, beginning with phantom studies progressing to, arguably, the most complex application yet attempted, cardiac MRE in vivo on a mouse model to assess myocardial stiffness in healthy and pathological subjects. Prior to attempting in vivo cardiac MRE on the mouse model, several pilot studies were conducted on phantom models to advance the technique.;A wideband phantom study was conducted to improve viscoelastic model identification. In order to better understand mechanical wave motion in geometry similar to the left ventricle, MRE experiments on a liquid-filled spherical shell phantom embedded in a soft tissue mimicking material were also conducted. Computational finite element simulations on a three dimensional model of a mouse with different actuation methods were also performed to improve understanding of how mechanical waves propagate into the complicated geometry of the mouse body, and how the tissue responds under different actuation approaches. An in vivo mouse cardiac MRE technique was then developed and tested on a healthy mouse model. This technique is able to track expected stiffness changes in the myocardium as a function of the cardiac cycle. And the results showed the feasibility of this implementation of in vivo cardiac MRE on mice. A follow-up study of applying the cardiac MRE on a Myocardial Infarcted (MI) mouse model was then conducted to assess the ability to noninvasively quantify expected changes in the myocardial mechanical properties of these animals, relative to the healthy cases.
机译：磁共振弹性成像（MRE）于1995年首次提出，以其非侵入性的方式估计软组织硬度的能力吸引了越来越多的关注。除了经FDA认证的肝病诊断应用程序外，还已经在多个器官中对MRE进行了研究，作为各种疾病诊断中潜在的新生物标记，尤其是近年来。除了在疾病诊断中的应用外，MRE还被用于监测工程组织的发展以及组织粘弹性的更基础的研究。本论文旨在推动高场MRE在复杂解剖结构上的应用，从幻象研究开始可以说是迄今为止尚未尝试过的最复杂的应用，即在小鼠模型上体内进行心脏MRE评估健康和病理对象的心肌僵硬程度。在尝试在小鼠模型上进行体内心脏MRE之前，先对体模模型进行了一些初步研究以改进该技术。进行了宽带体模研究以改善粘弹性模型的识别。为了更好地理解类似于左心室的几何形状中的机械波运动，还对嵌入在软组织模拟材料中的液体填充球形壳模型进行了MRE实验。还使用不同的驱动方法对鼠标的三维模型进行了计算有限元模拟，以增进对机械波如何传播到鼠标主体的复杂几何形状以及组织在不同的驱动方式下的响应方式的了解。然后开发了体内小鼠心脏MRE技术，并在健康的小鼠模型上进行了测试。该技术能够追踪心肌的预期硬度随心动周期的变化。结果表明，在小鼠上实施体内心脏MRE的可行性。然后进行了将心脏MRE应用于心肌梗塞（MI）小鼠模型的后续研究，以评估相对于健康病例，无创量化这些动物的心肌力学特性预期变化的能力。

著录项

  • 作者

    Liu, Yifei.;

  • 作者单位

    University of Illinois at Chicago.;

  • 授予单位 University of Illinois at Chicago.;
  • 学科 Mechanical engineering.;Medical imaging.;Biomedical engineering.
  • 学位 Ph.D.
  • 年度 2015
  • 页码 162 p.
  • 总页数 162
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 遥感技术;
  • 关键词

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