首页> 外文学位 >Risk factors for high-risk, oncogenic human papillomavirus (HPV) anal infection in HIV-positive and HIV-negative men who have sex with men (MSM).
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Risk factors for high-risk, oncogenic human papillomavirus (HPV) anal infection in HIV-positive and HIV-negative men who have sex with men (MSM).

机译:与男性发生性行为的HIV阳性和HIV阴性男性高危,致癌性人乳头瘤病毒(HPV)肛门感染的危险因素。

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摘要

Background: Most anal cancers are caused by high-risk (HR)-HPV, occurring at much higher rates in MSM. There is little evidence on specific risk factors for HR-HPV in this population.;Objective: To determine sexual and behavioural risk factors for HR-HPV anal canal infection.;Methods: Cross-sectional study recruiting a clinic-based MSM sample. Participants completed a questionnaire, and had HPV/STI testing. Multivariable logistic regression was performed to assess HR-HPV risk factors.;Results: 442 MSM were recruited: 267 HR-HPV-positive, 162 HR-HPV-negative. Multivariable analyses revealed risk factors associated with HR-HPV infection: HIV status (OR: 1.86, 95% CI 1.20-2.89); current smoking status (OR: 2.24, 95% CI 1.33-3.79); and >50 lifetime sexual partners (OR: 2.37, 95% CI 1.05-5.35).;Conclusions: This study highlights important risk factors for HR-HPV anal infection. On a background of limited evidence for HPV screening modalities, this information may shed light on novel ways to risk stratify MSM to further anal cancer screening interventions.
机译:背景:大多数肛门癌是由高危(HR)-HPV引起的,在MSM中发生率更高。在这一人群中,关于HR-HPV的特定危险因素的证据很少。目的:确定HR-HPV肛管感染的性和行为危险因素。方法:横断面研究招募基于临床的MSM样本。参与者完成了问卷调查,并进行了HPV / STI测试。结果:募集了442例MSM:267例HR-HPV阳性,162例HR-HPV阴性。多变量分析显示与HR-HPV感染相关的危险因素:HIV状况(OR:1.86,95%CI 1.20-2.89);当前吸烟状况(OR:2.24,95%CI 1.33-3.79);以及> 50个终生性伴侣(或:2.37,95%CI 1.05-5.35)。;结论:这项研究着重指出了HR-HPV肛门感染的重要危险因素。在有关HPV筛查方式的证据有限的背景下,此信息可能有助于阐明将MSM分层以进一步进行肛门癌筛查干预措施的新方法。

著录项

  • 作者

    Grennan, J. Troy.;

  • 作者单位

    University of Toronto (Canada).;

  • 授予单位 University of Toronto (Canada).;
  • 学科 Medicine.;Epidemiology.;Virology.
  • 学位 M.Sc.
  • 年度 2015
  • 页码 68 p.
  • 总页数 68
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

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