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首页> 外文学位 >An Injectable Thermosensitive Biodegradable Hydrogel Embedded with Snap Containing PLLA Microparticles for Sustained Nitric Oxide (NO) Delivery for Wound Healing
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An Injectable Thermosensitive Biodegradable Hydrogel Embedded with Snap Containing PLLA Microparticles for Sustained Nitric Oxide (NO) Delivery for Wound Healing

机译：可植入热敏性可生物降解的水凝胶，其嵌入有含Snap的PLLA微粒，用于持续输送一氧化氮（NO）以进行伤口愈合。

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摘要

After injury, wound healing is a complex sequential cascade of events essential for the proper recovery of the wound without the scar formation. Nitric oxide (NO) is a small, endogenous free-radical gas with antimicrobial, vasodilating and growth factor stimulating properties. NO has wide biomedical application especially in wound healing however, its usability is hindered due its administration problem as it is highly unstable.;In this work, poly (l-lactic acid) microparticles encapsulated with NO donor S-nitroso-N-acetyl-D-penicillamine (SNAP) were prepared using water-in-oil-water double emulsion solvent evaporation method for controlled delivery for NO at the specific site. The NO release from SNAP-PLLA microparticles prepared at two different stirring speeds (500 and 2500 RPM) was evaluated using three main SNAP decomposition triggers i.e. light, copper and ascorbic acid. The light controlled on and off mechanism of nitric oxide release from the microparticles at different intensities was demonstrated that can be used to control the amount of NO release depending on the need. An average total NO release of 6.11 +/- 1.71 x10-08 for 9 hrs. and 8.43 +/- 2.92 x10-08 for 13 hrs. was observed from microparticle (500) and microparticle(2500) respectively on exposure to light, copper (II) and ascorbate. Furthermore, these SNAP-PLLA microparticles were embedded into thermosensitive chitosan-agarose hydrogel to form microparticle-hydrogel composite. These composites have demonstrated NO release on exposure to light. An ascorbic acid chitosan-agarose hydrogel composite system was also used to evaluate the NO release in the presence of only ascorbic acid from the microparticle hydrogel composite. A significant difference in average total NO release from both microparticles as well as microparticle-hydrogel composite was observed because of varying size parameter. These findings suggest that these microparticle as well as microparticle-hydrogel composite formulations may be useful for wound site administration of nitric oxide to accelerate wound healing process delayed due to dysfunction in endogenous NO production caused by pathological infection.
机译：受伤后，伤口愈合是一系列复杂的顺序事件，对于正确恢复伤口而无疤痕形成至关重要。一氧化氮（NO）是一种小的内源性自由基气体，具有抗菌，血管舒张和生长因子刺激的特性。 NO尤其在伤口愈合方面具有广泛的生物医学应用价值，但由于其给药不稳定，因此其可用性受到阻碍，因为其高度不稳定。;在这项工作中，用NO供体S-亚硝基-N-乙酰基- D-青霉胺（SNAP）采用油包水双乳化溶剂蒸发法制备，以控制特定位置的NO的传递。使用三种主要的SNAP分解触发剂（即光，铜和抗坏血酸）评估了以两种不同的搅拌速度（500和2500 RPM）制备的SNAP-PLLA微粒的NO释放量。证明了在不同强度下从微粒释放一氧化氮的光控开和关机制，可根据需要用于控制NO释放量。 9小时的平均总NO释放量为6.11 +/- 1.71 x10-08。和8.43 +/- 2.92 x10-08，持续13小时。当暴露于光，铜（II）和抗坏血酸盐时，分别从微粒（500）和微粒（2500）观察到了α-射线。此外，将这些SNAP-PLLA微粒嵌入热敏壳聚糖-琼脂糖水凝胶中以形成微粒-水凝胶复合物。这些复合材料已证明暴露于光下不会释放NO。抗坏血酸壳聚糖-琼脂糖水凝胶复合系统也用于评估在微粒水凝胶复合物中仅存在抗坏血酸的情况下NO的释放。由于尺寸参数的变化，从两个微粒以及微粒-水凝胶复合材料释放的平均总NO释放量存在显着差异。这些发现表明，这些微粒以及微粒-水凝胶复合制剂可用于一氧化氮的伤口部位施用，以加速由于病理感染引起的内源性NO产生功能障碍而延迟的伤口愈合过程。

著录项

  • 作者

    Mittal, Nikhil.;

  • 作者单位

    Michigan Technological University.;

  • 授予单位 Michigan Technological University.;
  • 学科 Biomedical engineering.
  • 学位 M.S.
  • 年度 2018
  • 页码 122 p.
  • 总页数 122
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

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