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Functional silane based co-polymers for biofunctionalization studies, chemical sensing and separations.

机译：用于生物功能化研究，化学传感和分离的功能性硅烷基共聚物。

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摘要

The focus of the research reported in this dissertation has focused on two areas: (1) Synthesis of silane-containing polymers and (2) the application of these polymers to surface modification of substrates such as PDMS (for microfluidic applications), glass, quartz, silicon wafers and various nanoparticles (magnetic iron oxide, silica) for use in chemical and biological sensing and separation applications as well as in biofunctionalization of magnetic nanoparticles.;From the library of silane containing co- and terpolymer prepared with various susbtituted maleimides are characterized by FTIR, UV-Visible, 1H- and 13C-NMR, TGA and DSC. These structures are being explored for their use in chemical sensing and separations of explosive and amines and other species. A facile biofunctionalization of magnetic and silica nanoparticles is also describe in this dissertation. The ability to biofunctionalize these materials allows for their potential application in the biomedical field where they can be used in detection and in targeted drug delivery.;Also described herein is the functionalization of microfluidics systems for bioanalysis. Surface modification with silica nanoparticles would be a promising technique to provide an excellent interface on the conventional polymer surface. A sensitive biofunctionalization is carried in microfluidic chips. The antigens attached to the surface modified silanes via urea linkage and successful binding of antigens and antibodies is observed and can preserve the bioactivity of the antigens and antibodies and resist non specific adsorption. This study can be extended for a high-throughput system for bio-marker proteins.;Finally, we demonstrated the applicability of these polymers for sensing amines and nitro compounds. Substitutions on the phenyl ring help in tuning the sensitivity of these polymers to various amines including very weak aromatic amines. Increase in the intensity of fluorescence and a very noticeable change in color of the polymer solutions in presence of amines helps in their detection. This work represents our ability to design, control and utilize novel materials for various applications.
机译：本论文报道的研究重点集中在两个领域：（1）含硅烷的聚合物的合成；（2）这些聚合物在PDMS（用于微流体应用），玻璃，石英等基材的表面改性中的应用。 ，用于化学和生物传感和分离应用以及磁性纳米粒子的生物功能化的硅片和各种纳米粒子（磁性氧化铁，二氧化硅）。；从含硅烷的库中表征了各种可取代的马来酰亚胺制备的共聚物和三元共聚物FTIR，UV-Visible，1H和13C-NMR，TGA和DSC分析。人们正在探索将这些结构用于化学传感以及爆炸物，胺和其他物质的分离。本文还描述了磁性纳米粒子和二氧化硅纳米粒子的简便生物功能化。使这些材料生物功能化的能力允许它们在生物医学领域中的潜在应用，在这些领域中它们可用于检测和靶向药物递送。本文还描述了用于生物分析的微流体系统的功能化。用二氧化硅纳米粒子进行表面改性将是在常规聚合物表面上提供优异界面的有前途的技术。微流控芯片中进行了敏感的生物功能化。观察到通过尿素键连接到表面改性的硅烷上的抗原以及抗原和抗体的成功结合，并且可以保留抗原和抗体的生物活性并抵抗非特异性吸附。这项研究可以扩展到生物标记蛋白的高通量系统。最后，我们证明了这些聚合物在检测胺和硝基化合物方面的适用性。苯环上的取代基有助于调节这些聚合物对各种胺（包括非常弱的芳族胺）的敏感性。在胺存在下，荧光强度的增强和聚合物溶液颜色的显着变化有助于其检测。这项工作代表了我们设计，控制和利用新颖材料用于各种应用的能力。

著录项

  • 作者

    Addagulla, Swapna.;

  • 作者单位

    University of Rhode Island.;

  • 授予单位 University of Rhode Island.;
  • 学科 Chemistry Analytical.
  • 学位 Ph.D.
  • 年度 2009
  • 页码 207 p.
  • 总页数 207
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

  • 入库时间 2022-08-17 11:38:00

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