首页> 外文学位 >The role of NUMB in human extravillous trophoblast cell migration and survival.

【24h】

The role of NUMB in human extravillous trophoblast cell migration and survival.

机译：NUMB在人类绒毛外滋养层细胞迁移和存活中的作用。

获取原文

获取原文并翻译 | 示例

页面导航

摘要
著录项
相似文献
相关主题

摘要

Placental growth and development depend on highly regulated extravillous trophoblast (EVT) function, such as proliferation, migration and invasion. NUMB has been reported to playa role in cell differentiation and proliferation. An established cell line (HTR8/SVneo) was used as a model to study the role of NUMB in invasive extravillous trophoblast cell migration and survival in the human placenta. Immunofluorescence showed the presence of NUMB at the plasma membrane and the cytoplasmic region in HTR8/Svneo cells. NUMB isoform 1 significantly increased EVT migration while NUMB knockdown decreased the rate of migration as compared to the negative control. Overexpression of Numb 1,3,4 and 8 did not influence cellular viability whereas Numb 2 overexpression decreased trophoblast viability significantly. We have demonstrated for the first time that Numb is expressed in human invasive extravillous trophoblasts and that its role is isoform-dependent. Dysregulation of NUMB expression/function may playa role in placental pathologies such as preeclampsia and IUGR.

机译：胎盘的生长和发育取决于高度调节的绒毛外滋养层（EVT）功能，例如增殖，迁移和侵袭。据报道NUMB在细胞分化和增殖中起作用。建立的细胞系（HTR8 / SVneo）被用作模型来研究NUMB在人类胎盘侵袭性绒毛外滋养层细胞迁移和存活中的作用。免疫荧光显示在HTR8 / Svneo细胞的质膜和细胞质区域存在NUMB。与阴性对照相比，NUMB亚型1显着增加了EVT迁移，而NUMB敲低降低了迁移速率。 Numb 1,3,4和8的过表达不会影响细胞活力，而Numb 2的过表达会显着降低滋养细胞的活力。我们首次证明了Numb在人类侵入性绒毛外滋养层细胞中表达，其作用是依赖于亚型的。 NUMB表达/功能失调可能在子痫前期和IUGR等胎盘病理中起作用。

著录项

作者
Haider, Maliha.;
展开▼
作者单位

University of Ottawa (Canada).;

展开▼
授予单位 University of Ottawa (Canada).;
学科 Biology Molecular.
学位 M.Sc.
年度 2009
页码 93 p.
总页数 93
原文格式 PDF
正文语种 eng
中图分类
关键词

相似文献

外文文献
中文文献
专利

1. Roles of Rho guanosine 5'-triphosphatase A, Rho kinases, and extracellular signal regulated kinase (1/2) in prostaglandin E2-mediated migration of first-trimester human extravillous trophoblast. [J] . Nicola C, Chirpac A, Lala PK, Endocrinology . 2008,第3期

机译：Rho鸟苷5'-三磷酸酶A，Rho激酶和细胞外信号调节激酶（1/2）在前列腺素E2介导的早孕人类绒毛外滋养层细胞迁移中的作用。
2. Up-regulation of alpha5-integrin by E-cadherin loss in hypoxia and its key role in the migration of extravillous trophoblast cells during early implantation. [J] . Arimoto Ishida E, Sakata M, Sawada K Endocrinology . 2009,第9期

机译：缺氧时E-钙黏着蛋白损失上调α5-整联蛋白及其在早期植入过程中在绒毛外滋养层细胞迁移中的关键作用。
3. The role of alpha 5 beta 1-integrin in the IGF-I-induced migration of extravillous trophoblast cells during the process of implantation [J] . M.Kabir-Salmani, S.Shiokawa, Y.Akimoto, Molecular human reproduction. . 2004,第1a2期

机译：在植入过程中，α5β1-整合素在IGF-I诱导的绒毛外滋养层细胞迁移中的作用
4. Leukemia Inhibitory Factor (LIF) and Vascular Endothelial Growth Factor (VEGF) diminish intensity of apoptosis in hypoxic human trophoblast: first- trimester versus term trophoblast cultures. [C] . DARIUSZ SZUKIEWICZ, MICHAL PYZLAK, ALEKSANDRA STANGRET, Recent advances in clinical medicine . 2010

机译：白血病抑制因子（LIF）和血管内皮生长因子（VEGF）降低了缺氧人滋养细胞的凋亡强度：早孕期与足月滋养层培养相比。
5. Role and Regulation of GMFγ Phosphorylation in Human Airway Smooth Muscle Cell Migration [D] . Gerlach, Brennan D. 2019

机译：人气通风平滑肌细胞迁移GMFγ磷酸化的作用和调节
6. Spatiotemporal expression of SERPINE2 in the human placenta and its role in extravillous trophoblast migration and invasion [O] . Schu-Rern Chern, Sheng-Hsiang Li, Chien-Ling Chiu, 2011

机译：SERPINE2在人胎盘中的时空表达及其在绒毛外滋养细胞迁移和侵袭中的作用
7. EP1 Receptor-Mediated Migration of the First Trimester Human Extravillous Trophoblast: The Role of Intracellular Calcium and Calpain [O] . Catalin Nicola, Alexander V. Timoshenko, S. Jeffrey Dixon, 2005

机译：EP1受体介导的第一个三个月的迁移的人外向性滋养细胞：细胞内钙和钙骨的作用
8. Role of Integrins and IGFBPs in the IGF-1 Stimulated Migration of Human Breast Cancer Cells [R] . Zheng, B. , Clemmons, D. D. 1999

机译：整合素和IGFBps在IGF-1刺激的人乳腺癌细胞迁移中的作用

The role of NUMB in human extravillous trophoblast cell migration and survival.

摘要

著录项

相似文献

相关主题

期刊订阅