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Computational fluid dynamics modeling of two-dimensional and three-dimensional segmented flow in microfluidic chips.

机译：微流控芯片中二维和三维分段流动的计算流体动力学建模。

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摘要

Microfluidics is a rapidly growing topic of interest for scientists, engineers, and medical researchers. The micrometer length scale constrains flow to a laminar behavior, allowing for a more predictable system. High-throughput experimentation is possible with laminar multiphase flow, specifically microdroplets. Manipulating microdroplets by generating, splitting, separating, and fusing provides a versatile environment for analysis in a variety of biological and chemical systems.;The process of design, fabrication, and testing of microfluidic systems is an iterative and tedious procedure. The purpose of this research was to utilize computational fluid dynamics software to expedite the fabrication and design process by simulating time-dependent data as droplets flow through a channel. The two-dimensional segmented flow investigated the effect of droplet generation by inspecting three different nozzle widths combined with four different post nozzle designs. Droplets were successfully generated in all nozzle widths and all post nozzle geometries, but certain nozzle and post nozzle geometries were found to be a more efficient combination. The three-dimensional project analyzes droplet generation and merging in a pillar induced merging chamber. Multiple droplets successfully merged in the three-dimensional analysis.
机译：微流体技术是科学家，工程师和医学研究人员关注的一个快速增长的主题。千分尺长度刻度将流量限制为层流行为，从而使系统更加可预测。层流多相流，特别是微滴，可以进行高通量实验。通过生成，拆分，分离和融合来操纵微滴，为在各种生物和化学系统中进行分析提供了通用的环境。微流控系统的设计，制造和测试过程是一个反复且繁琐的过程。这项研究的目的是利用计算流体动力学软件通过模拟液滴流过通道的时间相关数据来加快制造和设计过程。二维分段流通过检查三种不同的喷嘴宽度和四种不同的后喷嘴设计来研究液滴产生的影响。在所有喷嘴宽度和所有后喷嘴几何形状中均成功生成了液滴，但是发现某些喷嘴和后喷嘴几何形状是更有效的组合。该三维项目分析了在立柱诱导的融合室中液滴的产生和融合。多个液滴在三维分析中成功合并。

著录项

  • 作者

    Donovan, Katrina J.;

  • 作者单位

    San Jose State University.;

  • 授予单位 San Jose State University.;
  • 学科 Nanotechnology.;Chemistry General.;Physics Fluid and Plasma.
  • 学位 M.S.
  • 年度 2014
  • 页码 60 p.
  • 总页数 60
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

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