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首页> 外文学位 >Withdrawal periods following extended access cocaine self-administration do not alter drug intake during binge or resistance to punished cocaine self-administration relapse.
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Withdrawal periods following extended access cocaine self-administration do not alter drug intake during binge or resistance to punished cocaine self-administration relapse.

机译：延长可卡因自我管理后的戒断期不会在暴饮暴食期间改变药物摄入量，也不会抵抗可卡因自我管理复发的抵抗力。

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摘要

Drug addiction is characterized as a chronic and relapsing disorder which persists despite long periods of abstinence from the drug. Changes in subjective craving for the drug have been reported to increase with long periods of abstinence, a phenomenon identified as incubation. Incubation is a time-dependent progressive increase in drug-seeking behavior elicited by cues previously associated with cocaine availability. While there have been many studies that have illustrated that length of withdrawal period is highly correlated to drug craving and seeking, this phenomenon does not seem to apply to traditional drug-induced relapse models. Here, we investigated the role of withdrawal periods on relapse to cocaine in "binge" and punishment models of cocaine self-administration. Rats were trained to self-administer cocaine in an extended access self administration paradigm (6 hour test sessions) for 10 days. After the final day of cocaine SA, rats were assigned to either a 1, 14 or 30 days of withdrawal period, following which rats were exposed to a 12-hour binge session where they were allowed unlimited access to cocaine. Drug addiction is further characterized by one's willingness to continue to take drugs despite negative consequences. We established a punishment model where following withdrawal (1 or 14 days) from cocaine self-administration, rats were then given a histamine/cocaine mixture for 6 hours.;Surprisingly, despite the imposed 14 and 30 day withdrawal periods, animals self-administered an equal amount of cocaine during the 12-hour binge as animals with a brief 1 day withdrawal period. Similar results were observed during the punishment relapse model. Animals exposed to a 14-day withdrawal took the same amount of drug as animals exposed to 1-day withdrawal despite that the drug intake had a negative consequence. Although these data do not support the incubation hypothesis, the findings demonstrate a great deal of stability of drug-taking behavior despite time of abstinence. We are preparing to examine the transcriptional mechanisms that mediate such behavioral stability in an attempt to identify novel molecular targets that may provide a therapeutic intervention.
机译：吸毒成瘾是一种慢性和复发性疾病，尽管长期戒酒仍持续存在。据报道，长期禁欲会增加药物对主观渴望的变化，这种现象被认为是温育。孵化是由先前与可卡因可利用性有关的线索引起的药物寻找行为的时间依赖性逐步增加。尽管有许多研究表明停药期的长短与药物的渴望和寻求高度相关，但这种现象似乎不适用于传统的药物诱发的复发模型。在这里，我们调查了戒断期在可卡因自我管理的“暴饮暴食”和惩罚模型中对可卡因复发的作用。在扩展访问自我管理范式（6小时测试）中训练大鼠自我管理可卡因，持续10天。在可卡因SA的最后一天之后，将大鼠分为1天，14天或30天的戒断期，此后将大鼠暴露于12小时的暴饮暴食期，让他们无限制地使用可卡因。吸毒成瘾的特征还在于尽管有负面后果，一个人仍然愿意继续吸毒。我们建立了一种惩罚模型，在这种模型中，可卡因自用药后（1或14天）停药后，大鼠被给予了组胺/可卡因混合物6小时;令人惊讶的是，尽管有14天和30天的停药期，动物还是自用在12小时的暴饮暴食中，可卡因的摄入量与动物相当，但撤药时间为1天。在惩罚复发模型中观察到相似的结果。禁食14天的动物与禁食1天的动物服用相同数量的药物，尽管药物摄入量具有负面影响。尽管这些数据不支持孵化假说，但是这些发现表明尽管有禁欲时间，但吸毒行为仍具有很大的稳定性。我们正在准备研究介导这种行为稳定性的转录机制，以试图确定可能提供治疗干预的新型分子靶标。

著录项

  • 作者

    Adank, Danielle N.;

  • 作者单位

    State University of New York at Buffalo.;

  • 授予单位 State University of New York at Buffalo.;
  • 学科 Health Sciences Pharmacology.;Biology Neuroscience.;Psychology Behavioral.
  • 学位 M.S.
  • 年度 2014
  • 页码 64 p.
  • 总页数 64
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

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