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Low-noise, low-power transimpedance amplifier for integrated electrochemical biosensor applications.

机译：适用于集成电化学生物传感器应用的低噪声，低功率跨阻放大器。

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摘要

Biosensor devices have found an increasingly broad range of applications including clinical, biological, and even pharmaceutical research and testing. These devices are useful for detecting chemical compounds in solutions and tissues. Current visual or optical methods include fluorescence and bio/chemiluminescence based detection. These methods involve adding luminescent dyes or fluorescent tags to cells or tissue samples to track movement in response to a stimulus. These methods often harm living tissue and interfere with natural cell movement and function.;Electrochemical biosensing methods may be used without adding potentially harmful dyes or chemicals to living tissues. Electrochemical sensing may be used, on the condition that the desired analyte is electrochemically active, and with the assumption that other compounds present are not electrochemically active at the reduction or oxidation potential of the desired analyte. A wide range of analytes can be selectively detected by specifically setting the potential of the solution using a potentiostat. The resulting small-magnitude current must then be converted to a measurable voltage and read using a low-noise transimpedance amplifier.;To provide spatial resolution on the intra-cellular level, a large number of electrodes must be used. To measure electrochemical signals in parallel, each electrode requires a minimum of a transimpedance amplifier, as well as other supporting circuitry. Low power consumption is a requirement for the circuitry to avoid generating large amounts of heat, and small size is necessary to limit silicon area.;This thesis proposes the design of a low-noise, low-power transimpedance amplifier for application in integrated electrochemical biosensor devices. The final proposed design achieves a 5MO transimpedance gain with 981aA/(square root of Hz) input inferred noise, 8.06muW at 0.9V power supply, and occupies a silicon area of 0.0074mm2 in a commercial 0.18mum CMOS process. This thesis also explores the development of a multi-channel electrochemical measurement system.
机译：生物传感器设备已经发现了越来越广泛的应用，包括临床，生物学甚至药物研究和测试。这些设备可用于检测溶液和组织中的化学化合物。当前的视觉或光学方法包括荧光和基于生物/化学发光的检测。这些方法涉及将发光染料或荧光标签添加到细胞或组织样品中，以跟踪响应刺激的运动。这些方法通常会伤害活组织并干扰自然细胞的移动和功能。可以使用电化学生物传感方法，而不向活组织中添加潜在有害的染料或化学物质。在期望的分析物具有电化学活性的条件下，并且假设存在的其他化合物在期望的分析物的还原或氧化电位下不具有电化学活性，可以使用电化学感测。通过使用恒电位仪专门设置溶液的电位，可以选择性地检测多种分析物。然后必须将产生的小幅度电流转换为可测量的电压，并使用低噪声跨阻放大器进行读取。为了在细胞内水平上提供空间分辨率，必须使用大量电极。为了并行地测量电化学信号，每个电极都需要最少的跨阻放大器以及其他支持电路。低功耗是避免产生大量热量的电路要求，并且小尺寸是限制硅面积的必要条件。;本文提出了一种用于集成电化学生物传感器的低噪声，低功率跨阻放大器的设计。设备。最终提出的设计以981aA / Hz的输入推断噪声实现了5MO跨阻增益，在0.9V电源下为8.06μW，在商用0.18μmCMOS工艺中占用的硅面积为0.0074mm2。本文还探讨了多通道电化学测量系统的发展。

著录项

  • 作者

    Wilson, William.;

  • 作者单位

    Colorado State University.;

  • 授予单位 Colorado State University.;
  • 学科 Engineering Electronics and Electrical.
  • 学位 M.S.
  • 年度 2014
  • 页码 125 p.
  • 总页数 125
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

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