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Direct writing of polymeric coatings for corrosion control and tunable release of bioactive materials.

机译：直接编写聚合物涂层以控制腐蚀和生物活性材料的可调释放。

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摘要

The interface between a medical device and its surrounding tissue can be critical to biocompatibility, performance and therapeutic effectiveness. Careful choice and application of materials at this interface is therefore a key to the success of any medical device. This research employed a novel direct-write inkjet printing technique for polymeric surface modification of bioresorbable AZ31 Mg alloy towards corrosion control and tunable release of bioactive agents.;In the first phase of this research, the direct-write inkjet printing technique was successfully used to fabricate thin films of different blends of poly (ester-urethane) urea embedded with taxol coatings on mechanically polished AZ31 Mg coupons. A corrosion study was performed using the electrochemical impedance spectroscopy (EIS) technique. The polarization resistance values obtained using the equivalent circuit model were analyzed using the ECHEM analyst commercial software developed by GamryRTM. The polarization resistances obtained indicated that the corrosion resistance of the polymeric materials increases in this order: uncoated AZ31 < PEUU-SB < PEUU-PC < PEUU-V.;In the second phase, thin films of PCL-ACP polymeric coatings were deposited on mechanically polished Ti, AZ31 and AZ31 pre-treated with HF substrates. The effect of ACP concentration and substrate type on cell proliferation was studied. Cyto-compatibility studies showed that osteoblast were biocompatible and displayed active proliferation for PCL-ACP coatings of different substrates. Osteoblast viability studies conducted using Ti coated substrates, showed higher percentage of viable osteoblast comparable to the positive controls (bare Ti and TCPS). These results lay foundation for the use of the direct-write fabrication technique for developing bioresorbable medical implants towards corrosion control and tunable release of bioactive agents.
机译：医疗设备及其周围组织之间的界面对于生物相容性，性能和治疗效果至关重要。因此，在此界面上仔细选择和应用材料是任何医疗设备成功的关键。这项研究采用了一种新颖的直接喷墨印刷技术，对可生物吸收的AZ31镁合金进行聚合物表面改性，以控制腐蚀和调节生物活性剂的释放。在机械抛光的AZ31 Mg试样上制造嵌入有紫杉醇涂层的聚（酯-氨基甲酸酯）尿素的不同混合物的薄膜。使用电化学阻抗谱（EIS）技术进行了腐蚀研究。使用由GamryRTM开发的ECHEM分析仪商业软件分析了使用等效电路模型获得的极化电阻值。所获得的耐极化性表明聚合物材料的耐腐蚀性按此顺序增加：未涂覆的AZ31

著录项

  • 作者

    Adarkwa, Eben.;

  • 作者单位

    North Carolina Agricultural and Technical State University.;

  • 授予单位 North Carolina Agricultural and Technical State University.;
  • 学科 Mechanical engineering.;Industrial engineering.;Biomedical engineering.
  • 学位 Ph.D.
  • 年度 2014
  • 页码 136 p.
  • 总页数 136
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

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