• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文学位 >An examination of the effects of chronic caffeine and withdrawal from chronic caffeine on fear conditioning in pre-adolescent, adolescent, and adult C57BL/6J mice.
【24h】

An examination of the effects of chronic caffeine and withdrawal from chronic caffeine on fear conditioning in pre-adolescent, adolescent, and adult C57BL/6J mice.

机译：检查慢性咖啡因和退出慢性咖啡因对青春期前，青春期和成年C57BL / 6J小鼠的恐惧状况的影响。

获取原文
获取原文并翻译 | 示例
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Caffeine is the most widely used psychoactive substance in the world. While findings suggest that chronic caffeine exerts negligible effects on cognition in adults, the effects of chronic caffeine on cognition in children and adolescents are not well understood. The hippocampus, a brain region important for learning and memory, undergoes extensive structural and functional modifications during pre-adolescence and adolescence. As a result, chronic caffeine may have differential effects on hippocampus-dependent learning and memory in pre-adolescents and adolescents compared to adults. The present study characterized the effects of chronic caffeine and withdrawal from chronic caffeine on hippocampus-dependent (contextual) and hippocampus-independent (cued) fear conditioning in pre-adolescent, adolescent, and adult mice. In addition, we investigated whether exposure to chronic caffeine during pre-adolescence, adolescence, or adulthood had long-lasting effects on conditioning in adulthood. Results indicate that exposure to chronic caffeine during pre-adolescence and adolescence either enhances or impairs contextual conditioning in a concentration-dependent manner. However, withdrawal from chronic caffeine impairs contextual conditioning in pre-adolescent mice only. In addition, exposure to chronic caffeine during pre-adolescence either enhances or impairs retention of contextual memories in adulthood in a concentration-dependent manner. In contrast, exposure to chronic caffeine during adolescence impairs cued conditioning in adulthood. These findings support the hypothesis that exposure to chronic caffeine during pre-adolescence and adolescence compromises hippocampus-dependent learning and memory. Furthermore, exposure to chronic caffeine during adolescence may produce long-lasting deficits in learning and memory in adulthood.
机译：咖啡因是世界上使用最广泛的精神活性物质。尽管研究结果表明，慢性咖啡因对成年人的认知影响可忽略不计，但对咖啡因对儿童和青少年认知的影响却知之甚少。海马是学习和记忆的重要大脑区域，在青春期前和青春期经历了广泛的结构和功能改变。结果，与成人相比，慢性咖啡因可能对青春期前和青少年的海马依赖性学习和记忆产生不同的影响。本研究的特点是慢性咖啡因和慢性咖啡因的戒断对青春期前，青春期和成年小鼠海马依赖性（上下文）和海马非依赖性（提示）恐惧条件的影响。此外，我们调查了在青春期前，青春期或成年期接触慢性咖啡因是否会对成年期的调理产生持久影响。结果表明，青春期前和青春期接触慢性咖啡因会以浓度依赖的方式增强或削弱情境调节。但是，从慢性咖啡因中撤药仅会损害青春期前小鼠的环境条件。另外，青春期前暴露于慢性咖啡因会以浓度依赖的方式增强或损害成年期上下文记忆的保持。相反，在青春期期间暴露于慢性咖啡因会削弱成年期提示的适应性。这些发现支持这样的假说，即青春期前和青春期接触慢性咖啡因会损害海马依赖性学习和记忆。此外，在青春期接触慢性咖啡因可能会导致成年后学习和记忆的长期缺陷。

著录项

  • 作者

    Poole, Rachel Lucile Flagg.;

  • 作者单位

    Temple University.;

  • 授予单位 Temple University.;
  • 学科 Behavioral psychology.;Neurosciences.;Pharmacology.
  • 学位 Ph.D.
  • 年度 2014
  • 页码 121 p.
  • 总页数 121
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号