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首页> 外文学位 >Longitudinal predictors of quality of life in adolescent survivors of childhood cancer: A report from the childhood cancer survivor study.
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Longitudinal predictors of quality of life in adolescent survivors of childhood cancer: A report from the childhood cancer survivor study.

机译：儿童癌症青少年幸存者生活质量的纵向预测因素：儿童癌症幸存者研究的报告。

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摘要

Objective: The impact of childhood cancer on future quality of life (QoL) in survivors is unclear. Current studies focus on comparing outcomes to healthy peers and identifying related treatment and demographic variables, but a shift in our approach is necessary. This study is guided by the Wilson and Cleary Model (WMC) and seeks to identify longitudinal predictors of QoL in adolescent survivors of cancer that explain variance in QoL beyond the impact of treatment and demographic variables. Methods: The Childhood Cancer Survivor Study (CCSS) is a multi-institutional longitudinal study following a cohort of childhood cancer survivors. This study focuses on the CCSS cohort (N = 305) who completed the baseline survey in 1994 and the Teen survey in 2001. The baseline survey assessed parent-report of child's psychological and physical symptoms, functional status, and health perceptions. The Teen survey utilized the Child Health and Illness Profile - Adolescent Edition (CHIP-AE), a self-report measure assessing QoL in six domains: achievement, resilience, satisfaction, discomfort, disorders, and risk. The primary hypothesis was that psychological and physical symptoms, functional status impairment, and health perceptions as rated by parents at baseline would predict variance in quality of life as rated by adolescents at follow-up after adjusting for demographic and treatment-related variables. Six separate hierarchical regressions were analyzed for each of the QoL domains. Results: The main hypothesis was supported. For each QoL outcome, a significant amount of variance was predicted: achievement, F (6, 259) = 8.90, p < .001, adjusted R2 = .152, resilience, F (12, 209) = 3.47, p < .001, adjusted R 2 = .118, satisfaction, F (6, 265) = 8.73, p < .001, adjusted R2 = .146, discomfort, F (7, 273) = 6.75, p < .001, adjusted R 2 = .126, disorders, F (9, 212) = 6.47, p < .0001, adjusted R2 = .182, and risk, F (7, 238) = 4.81, p < .001, adjusted R 2 = .098. Furthermore, for all outcomes, psychological and physical symptoms, functional status impairment, and health perceptions predicted variance above and beyond the impact of demographic and treatment variables. These factors accounted for an additional 9.5% of the variance in the achievement domain, 6.2% for resilience, 10.8% for satisfaction, 6.5% for discomfort, 12.4% for disorders, and 6.1% for risk. Conclusions: Results suggest that psychological and physical symptoms, functional status and health perceptions should be assessed and targeted in interventions for childhood cancer survivors to promote future positive QoL. Future studies need to continue identifying factors related to positive long-term functioning in diverse samples of childhood cancer survivors.
机译：目的：尚不清楚儿童癌症对幸存者未来生活质量（QoL）的影响。当前的研究重点是与健康同龄人比较结局，并确定相关的治疗方法和人口统计学变量，但是我们的方法必须转变。这项研究以Wilson and Cleary模型（WMC）为指导，力图确定青春期癌症幸存者中QoL的纵向预测因素，这些纵向预测因素可以解释QoL的变化超出治疗和人口统计学变量的影响。方法：儿童癌症幸存者研究（CCSS）是一项多机构纵向研究，其研究对象是儿童癌症幸存者。这项研究的重点是CCSS队列（N = 305），他们于1994年完成了基线调查，并于2001年完成了青少年调查。基线调查评估了父母对孩子的心理和身体症状，功能状态以及健康感知的报告。青少年调查使用了《儿童健康和疾病概况-青少年版》（CHIP-AE），这是一项自我评估指标，用于评估六个方面的QoL：成就，适应力，满意度，不适感，疾病和风险。主要假设是，在调整了人口统计学和与治疗相关的变量后，父母在基线时所评估的心理和身体症状，功能状态障碍以及健康感知将预测青少年在随访时所评估的生活质量差异。针对每个QoL域分析了六个单独的层次回归。结果：主要假设得到支持。对于每个QoL结果，都预测会有大量差异：成就，F（6，259）= 8.90，p <.001，调整后的R2 = .152，复原力，F（12，209）= 3.47，p <.001 ，调整后的R 2 = .118，满意度，F（6，265）= 8.73，p <.001，调整后的R2 = .146，不适，F（7，273）= 6.75，p <.001，调整后的R 2 = .126，障碍，F（9，212）= 6.47，p <.0001，调整后的R2 = .182，风险，F（7，238）= 4.81，p <.001，调整R 2 = .098。此外，对于所有结局，心理和身体症状，功能状态受损以及健康观念预测的差异将超出人口统计学和治疗变量的影响。这些因素占成就域方差的9.5％，复原力6.2％，满意度10.8％，不适6.5％，疾病12.4％，风险6.1％。结论：结果表明，应评估心理和生理症状，功能状态和健康感知，并针对儿童癌症幸存者进行干预，以促进未来积极的生活质量。未来的研究需要继续确定与儿童癌症幸存者样本不同的长期长期正功能相关的因素。

著录项

  • 作者

    Russell, Claire C.;

  • 作者单位

    Virginia Commonwealth University.;

  • 授予单位 Virginia Commonwealth University.;
  • 学科 Psychology Counseling.
  • 学位 Ph.D.
  • 年度 2014
  • 页码 119 p.
  • 总页数 119
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

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