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A Particle Engineering Approach for the Design of Structured Microparticles.

机译：设计结构化微粒的粒子工程方法。

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摘要

The process of microparticle formation from evaporating microdroplets is the main production method for many products. For most of these applications (especially pharmaceutical ones) the properties and morphology of the final dry particle have to be precisely tailored to ensure the proper functionality of the final product.;The present work discusses two aspects of the microparticle formation process, the evaporation rate and the transient concentration profiles. Although many other aspects are involved, it is thought that these two are the most influential ones.;Chapter one gives a brief introduction to the process of structured microparticle formation along with the important particle physical properties and the associated challenges. Chapter two and three introduce a new particle formation theory for the formation of microparticles when diffusion is the main mechanism of mass transport. They also introduce a simplification of the theory results through a hybrid analytical/numerical model to ease the use of the results.;Chapter four introduces a novel hybrid technique for calculation of the variable evaporation rate of microdroplets given knowledge of the droplet trajectory and the solvent material properties. A simplification of this approach is also proposed in the case when the trajectory data has a wide margin of uncertainty.;Particle engineering focuses on improving particle production processes by developing physical understanding and applying models to deliberately alter the properties of the particles.;In chapter five, the asymptotic state solution and the transient solution of the concentration profiles of an evaporating cylindrical cylinder were derived. These results are used to verify the new model proposed in chapters six and seven.;Chapter six and seven propose a new numerical model (The Adaptive Interface Sweeping Method) for the calculation of the transient concentration profiles of an evaporating solution droplet. This model is capable of modeling many physical mechanisms involved in the particle formation process. It also offers a viable technique in dealing with variable material properties and evaporation rates.;Chapter eight gives a brief discussion of the results introduced through the thesis and recommendations for future work.
机译：蒸发微滴形成微粒的过程是许多产品的主要生产方法。对于大多数这些应用（尤其是药物应用），必须精确地调整最终干燥颗粒的性质和形态，以确保最终产品的适当功能。本工作讨论了微粒形成过程的两个方面，即蒸发速率以及瞬态浓度曲线。尽管涉及到许多其他方面，但人们认为这两个方面最具影响力。第一章简要介绍了结构化微粒的形成过程以及重要的微粒物理性质和相关的挑战。第二章和第三章介绍了一种新的颗粒形成理论，即当扩散是质量传输的主要机理时，微粒形成的理论。他们还通过混合分析/数值模型介绍了简化理论结果的方法，以简化结果的使用。第四章介绍了一种新颖的混合技术，用于在已知液滴轨迹和溶剂的情况下计算微滴的可变蒸发速率。材料特性。在轨迹数据具有较大不确定性的情况下，还建议简化此方法。粒子工程的重点是通过发展物理理解和应用模型来故意改变粒子的特性，从而改善粒子的生产过程。第五，推导了蒸发圆柱体浓度分布的渐近状态解和瞬态解。这些结果用于验证第六章和第七章中提出的新模型。第六章和第七章提出了一种新的数值模型（自适应接口扫描方法），用于计算蒸发溶液液滴的瞬态浓度分布。该模型能够对粒子形成过程中涉及的许多物理机制进行建模。它还为处理可变的材料特性和蒸发速率提供了一种可行的技术。第八章简要讨论了通过论文介绍的结果并提出了对未来工作的建议。

著录项

  • 作者

    Boraey, Mohammed Abd El-Hameed Ahmed.;

  • 作者单位

    University of Alberta (Canada).;

  • 授予单位 University of Alberta (Canada).;
  • 学科 Mechanical engineering.;Plasma physics.;Pharmaceutical sciences.;Chemical engineering.
  • 学位 Ph.D.
  • 年度 2014
  • 页码 137 p.
  • 总页数 137
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 老年病学;
  • 关键词

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