首页> 外文学位 >The impact of developmental stress on cardiovascular physiology of two archosaur species: American alligator (Alligator mississippiensis ) and domestic chicken (Gallus gallus).
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The impact of developmental stress on cardiovascular physiology of two archosaur species: American alligator (Alligator mississippiensis ) and domestic chicken (Gallus gallus).

机译:发育应激对两种始祖鸟的心血管生理的影响:美国短吻鳄(Alligator mississippiensis)和家养鸡(Gallus gallus)。

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摘要

Crocodilians and birds comprise sister taxa of archosaurs, the development of these vertebrates occurs within an egg case that leaves developing embryos susceptible to fluctuations in the nesting environment. Studies suggest that sub-optimal conditions alter morphological growth and cardiovascular physiology. Regulation of the cardiovascular system is immature in the subjects studied, and embryos may rely on humoral rather than neural control of the cardiovascular system. The primary focus of this dissertation was to assess regulatory mechanisms responsible for maintenance of arterial pressure and heart rate.;Dehydration stress had marked effects on embryo growth, and altered baseline cardiovascular parameters, while leaving the response to humoral regulator, angiotensin II (Ang II), unaffected. However, dehydrated alligator embryos developed cholinergic tone on heart rate. Hypoxic incubated chicken embryos were reduced in embryo mass, and altered response to humoral regulatory components Ang I and adenosine in addition identifying a novel regulatory component of the cardiovascular response to acute hypoxia.;Collectively, these studies add to the existing knowledge of cardiovascular physiology in embryonic archosaurs and suggest that some components of cardiovascular regulation are plastic following developmental stress.
机译:鳄鱼和鸟类构成了恐龙的姊妹类群,这些脊椎动物的发育发生在卵壳内,使发育中的胚胎易受巢状环境波动的影响。研究表明,次优条件会改变形态生长和心血管生理。在研究的对象中,心血管系统的调节尚不成熟,胚胎可能依赖于体液而非神经系统的心血管控制。本论文的主要重点是评估负责维持动脉压和心率的调节机制。脱水压力对胚胎生长有显着影响,并改变了基线心血管参数,而对体液调节剂血管紧张素II(Ang II ),不受影响。然而,脱水的短吻鳄胚胎对心率产生胆碱能调。缺氧培养的鸡胚减少了胚的质量,并改变了对体液调节成分Ang I和腺苷的反应,此外还确定了对急性缺氧的心血管反应的新调节成分。总体而言,这些研究增加了心血管疾病的现有知识。胚胎考古学家,表明心血管调节的某些组成部分在发育应激后是可塑性的。

著录项

  • 作者

    Tate, Kevin B.;

  • 作者单位

    University of North Texas.;

  • 授予单位 University of North Texas.;
  • 学科 Physiology.;Developmental biology.
  • 学位 Ph.D.
  • 年度 2014
  • 页码 147 p.
  • 总页数 147
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

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