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Systems theory: A modified extracorporeal circuit to attenuate systemic inflammatory response syndrome.

机译：系统理论：一种改良的体外回路，可减轻全身炎症反应综合征。

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摘要

This dissertation explores the validity of utilizing a modified extracorporeal circuit to attenuate the systemic inflammatory response syndrome known as SIRS. Attention is directed specifically at the existence of this disease within the setting of cardiopulmonary bypass surgery, commonly referred to as CPB; a standard technique utilized when performing cardiac surgery. Effort is focused on how this new and innovative Pinnacle System enables the reduction of inflammation within this field of clinical surgery, as compared to that of the existing standard bypass system. This was achieved by measuring and comparing research results derived from both bypass systems, such results were obtained from 214 participants who were selected as secondary research samples. Quantitative research methodology was selected as the appropriate research technique, incorporating both a true prospective experimental design and random assignments of participants to equal groups; one such group was allocated to be operated on utilizing the standard bypass circuitry, and the second group were likewise allocated to the new Pinnacle System. This new circuitry incorporated improvisations to the surface coatings, reduction of the priming volume, reduction in both air and blood transit time within the extracorporeal circuitry, and removal of the air blood interface. In addition, the Pinnacle System offers unique circuit configuration characteristics, such as the ability to run an open or closed configuration thereby negating inflammatory mediators. The objective was to establish and measure the ability of the Pinnacle System to both enable the enhancement of hemocompatibility in the patient's blood when in contact with the circuit's artificial surfaces, and to determine the biocompatibility of the materials used in the construction of this new bypass system. Findings conducted by this research study suggest that Pinnacle System enhances post-operative results with less blood loss, less time of ventilation, reduction in the period spent in ICU and overall time of hospitalization; such positive outcomes enabling both financial savings and improved patient wellbeing. Perhaps future research can continue to further explore the possibilities enabled by this unique circuitry design thereby contributing to enhanced patient care, reduction in healthcare costs, and improved clinical efficiency.
机译：本文探讨了利用改良的体外回路减轻系统性炎症反应综合征（SIRS）的有效性。特别要注意的是在体外循环手术（通常称为CPB）中这种疾病的存在。进行心脏手术时使用的标准技术。与现有的标准旁路系统相比，这种新型创新型Pinnacle系统的工作重点是如何在临床手术领域内减轻炎症。这是通过测量和比较来自两个旁路系统的研究结果来实现的，这些结果是从被选为第二研究样本的214名参与者中获得的。选择定量研究方法作为适当的研究技术，既要考虑真实的前瞻性实验设计，又要把参与者随机分配到同等群体中；其中一组被分配使用标准旁路电路进行操作，第二组同样被分配给新的Pinnacle系统。这种新的电路将表面涂层的即兴创作，灌注量的减少，体外电路内空气和血液传输时间的减少以及空气与血液界面的去除都结合在一起。此外，Pinnacle系统具有独特的电路配置特征，例如能够运行打开或关闭配置，从而消除炎症介质。目的是建立并测量Pinnacle系统的能力，以增强与回路的人造表面接触时患者血液中的血液相容性，并确定用于构建这种新旁路系统的材料的生物相容性。 。这项研究的结果表明，品尼高系统可提高术后效果，减少失血量，减少通气时间，减少在ICU中的花费时间和整体住院时间。如此积极的成果既可以节省金钱，又可以改善患者的健康状况。也许未来的研究可以继续进一步探索这种独特的电路设计所带来的可能性，从而有助于提高患者护理水平，降低医疗保健成本并提高临床效率。

著录项

  • 作者

    McCusker, Kevin.;

  • 作者单位

    Capella University.;

  • 授予单位 Capella University.;
  • 学科 Health Sciences Surgery.
  • 学位 Ph.D.
  • 年度 2014
  • 页码 146 p.
  • 总页数 146
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

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