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首页> 外文学位 >Effects of acute THC administration on extinction of conditioned fear responses in humans: A functional analysis of high density EEG.
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Effects of acute THC administration on extinction of conditioned fear responses in humans: A functional analysis of high density EEG.

机译：急性四氢大麻酚给药对人类条件性恐惧反应消退的影响：高密度脑电图的功能分析。

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摘要

High density electroencephalographic (EEG) measures were used to assess the effects of acute delta 9-tetrahyrdrocannabidol (THC) administration on extinction of conditioned fear responses. Fear conditioning was initiated using a differential classical conditioning paradigm that paired an aversive unconditioned stimulus (shock) with a signaling stimulus (CS+), whereas another stimulus served as a safety signal (CS-). Evoked potentials, induced event-related spectral perturbations (ERSP), and associated intertrial coherence (ITC) measures were used to quantify the acquisition and extinction of conditioned fear responses. Participants (N = 10 males) exhibited conditioning to the CS+ across fear acquisition training, as reflected by greater late positive (posterior sites) and late negative (anterior sites) potential amplitude to the CS+ relative to the CS-. Acute administration of THC facilitated extinction of the conditioned response to the CS+ relative to placebo, as reflected by greater LPP and LNP amplitude to the CS+ relative to the CS- in the placebo, but not THC condition. ERSP analyses suggest the lack of difference between CS+ and CS- ERP amplitude may be partially explained by a shifting of attention from external stimuli to internal processing in the THC condition. However, relative to placebo, THC administration also increased the amplitude of some measures of the conditioned response (LNP) to the CS-, suggesting a generalization of fear or lack of discrimination in this condition.
机译：高密度脑电图（EEG）措施用于评估急性三角洲9-四氢大麻酚（THC）给药对条件性恐惧反应消退的影响。使用差分经典条件范式启动恐惧条件，该范式将厌恶的无条件刺激（冲击）与信号刺激（CS +）配对，而另一种刺激充当安全信号（CS-）。诱发电位，诱发事件相关光谱扰动（ERSP）和相关的间质相干性（ITC）措施用于量化条件性恐惧反应的获得和消灭。参与者（N = 10男性）在恐惧获取训练中表现出对CS +的调节，这反映为相对于CS-，CS +的晚期正（后部部位）和晚期负（前部部位）电位幅度更大。相对于安慰剂，THC的急性给药促进了对CS +的条件反应的消退，这反映在安慰剂中相对于CS-的CS +的LPP和LNP幅度更大，而THC则没有。 ERSP分析表明，在THC条件下，注意力从外部刺激转移到内部处理可能部分解释了CS +和CS-ERP幅度之间缺乏差异。但是，相对于安慰剂，THC给药还增加了对CS-的条件反应（LNP）的某些测量值的幅度，这表明这种情况下普遍存在恐惧或缺乏歧视。

著录项

  • 作者

    Diggs, Herman A.;

  • 作者单位

    Southern Illinois University at Carbondale.;

  • 授予单位 Southern Illinois University at Carbondale.;
  • 学科 Neurosciences.;Behavioral psychology.;Experimental psychology.
  • 学位 Ph.D.
  • 年度 2014
  • 页码 209 p.
  • 总页数 209
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

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