• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文学位 >Anatomically Realistic Structural Modeling of the Cardiac Purkinje Network A Basis for Studying Contributions of the Conduction System to Ventricular Arrhythmias.
【24h】

Anatomically Realistic Structural Modeling of the Cardiac Purkinje Network A Basis for Studying Contributions of the Conduction System to Ventricular Arrhythmias.

机译：心脏Purkinje网络的解剖学逼真的结构模型，是研究传导系统对室性心律失常贡献的基础。

获取原文
获取原文并翻译 | 示例
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

A cardiac arrhythmia is a potentially-lethal event in which the normally orderly electrical activity in the heart is disrupted -- it becomes disorganized and compromises effective contraction. To better understand arrhythmia dynamics to develop potential therapies and treatments, experimental, computational, and mathematical tools are required. Simulations of cardiac tissue provide valuable insight into the dynamics of life-threatening cardiac arrhythmias, and though much work has been done in this area, the role of the Purkinje network during ventricular arrhythmias has largely been ignored. The function of the Purkinje network is crucial to normal heart rhythm, so its inclusion into cardiac structural models is a necessary step to furthering our understanding of arrhythmias. Current technological limitations prevent the direct imaging of the intact three-dimensional Purkinje structure, making the incorporation of a Purkinje network into such simulations difficult. At this time most efforts involve generating artificial Purkinje networks either through manual drawing of Purkinje-like structures or through algorithms that generate the structures procedurally based on rules gleaned from physiological studies. Very little work has focused on the incorporation of a Purkinje network based directly on experimental data. Through dissection, photographs of the Purkinje network can be taken, but these two-dimensional photographs do not capture the three-dimensional structure of the network. Here we present a novel method for reconstructing the three-dimensional Purkinje structure based on projecting two-dimensional Purkinje structures recovered from experimental photographs onto realistic ventricular geometries. The resulting three-dimensional Purkinje structures make possible the modeling of the coupled ventricle-Purkinje system. The second major component of our work is the development of two methods by which these systems can be modeled. We implement these models using real anatomical data and find good agreement between the two models and with previous experimental studies. Our work provides a basis for the further study of ventricular arrhythmias, and in particular the role the Purkinje network plays in initiating and maintaining such events.
机译：心律失常是一种潜在的致命事件，其中心脏中通常有序的电活动被破坏-它变得混乱并且损害了有效的收缩。为了更好地了解心律失常动力学以开发潜在的疗法和治疗方法，需要实验，计算和数学工具。心脏组织的仿真为威胁生命的心律不齐的动态变化提供了宝贵的见识，尽管在这一领域已做了大量工作，但Purkinje网络在室性心律不齐中的作用已被大大忽略。 Purkinje网络的功能对于正常的心律至关重要，因此将其包含在心脏结构模型中是进一步加深我们对心律不齐的理解的必要步骤。当前的技术局限性阻止了对完整的三维Purkinje结构的直接成像，从而使得难以将Purkinje网络整合到这种模拟中。目前，大多数工作都涉及通过人工绘制类似Purkinje的结构或通过基于生理研究得出的规则从程序上生成结构的算法来生成人工Purkinje网络。很少有工作专注于直接基于实验数据合并Purkinje网络。通过解剖，可以拍摄浦肯野网络的照片，但是这些二维照片不能捕获网络的三维结构。在这里，我们提出了一种新的方法，该方法基于将从实验照片中回收的二维Purkinje结构投影到现实的心室几何结构上，从而重构三维Purkinje结构。由此产生的三维浦肯野结构使耦合心室-浦肯野系统的建模成为可能。我们工作的第二个主要组成部分是开发可以对这些系统建模的两种方法。我们使用真实的解剖数据实施这些模型，并在两个模型之间以及与先前的实验研究之间找到了很好的一致性。我们的工作为进一步研究室性心律失常提供了基础，尤其是浦肯野网络在引发和维持此类事件中的作用。

著录项

  • 作者

    Liu, Benjamin.;

  • 作者单位

    Rochester Institute of Technology.;

  • 授予单位 Rochester Institute of Technology.;
  • 学科 Applied Mathematics.
  • 学位 M.S.
  • 年度 2014
  • 页码 77 p.
  • 总页数 77
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 公共建筑;
  • 关键词

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号