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首页> 外文学位 >Development of Novel Magnetic Resonance Imaging Techniques to Evaluate Plasticity in the Injured Human Cervical Spinal Cord.
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Development of Novel Magnetic Resonance Imaging Techniques to Evaluate Plasticity in the Injured Human Cervical Spinal Cord.

机译：新型磁共振成像技术的发展，以评估人颈脊髓损伤中的可塑性。

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摘要

Traumatic injury to the human spinal cord is a devastating condition that results in motor and sensory impairment. The goal of this thesis is to develop magnetic resonance imaging techniques as a biomarker to evaluate the human spinal cord after injury. The specific aims are: 1a) to characterize the standard T1 and T2-weighted intramedullary spinal cord signal characteristics first used by clinicians treating spinal cord injury in order to classify patients along a spectrum of injury severity; 1b) to calculate the sensitivity and specificity of MRI biomarkers to determine neurological function and 1c) to determine whether standard T1 and T2-weighted imaging biomarkers offer an advantage over clinical examination to predict neurological outcomes. 2) To determine whether spinal functional MRI can be used to distinguish spinal cord injury patients from healthy controls by 2a) determining whether there is an abnormal neuro-vascular response to afferent stimulation in dermatomes of normal sensation, above the level of injury, in spinal cord injury (SCI) patients 2b) to determine whether the neuro-vascular response to afferent stimulation in dermatomes of altered sensory perception, below the level of injury, is correlated to the degree of sensory loss and 2c) to determine the functional connectivity between regions of the spinal cord that process an afferent stimulus and other regions of the brainstem-spinal cord axis. 3) To outline the diversity of segmental anatomy of the human spinal cord across a cohort of individuals by 3a) measuring the position of vertebral bodies and spinal cord segments relative to the ponto-medullary junction; 3b) to calculate the relative positions of vertebral bodies and spinal cord segments; and 3c) to predict the position of spinal cord segments. Results indicate that 1) standard T1 and T2-weighted intramedullary spinal cord signal characteristics offer no advantage over clinical examination to predict prognosis. 2) Spinal fMRI can be utilized to provide evidence of spinal cord plasticity after traumatic injury and 3) there is natural diversity of the position of vertebral and spinal cord segments relative to the ponto-medullary junction that should be taken into account for advanced imaging studies. Collectively, the new knowledge presented herein contributes to the advancement of imaging techniques to investigate the human spinal cord.
机译：对人脊髓的创伤性损伤是毁灭性的状况，其导致运动和感觉障碍。本文的目的是发展磁共振成像技术作为生物标记物，以评估损伤后的人类脊髓。具体目标是：1a）表征标准的T1和T2加权髓内脊髓信号特征，首先由临床医生治疗脊髓损伤，以便根据损伤的严重程度对患者进行分类； 1b）计算MRI生物标记物以确定神经功能的敏感性和特异性，以及1c）确定标准T1和T2加权成像生物标记物是否比临床检查更有利于预测神经功能。 2）确定是否可以通过2a）确定正常感觉的皮层中高于传入损伤水平的传入刺激对脊柱功能性MRI与正常对照组的脊髓损伤患者和健康对照组之间是否存在异常的神经血管反应脊髓损伤（SCI）患者2b）确定低于损伤水平的感觉感觉改变的皮膜中传入刺激的神经血管反应是否与感觉丧失程度相关; 2c）确定区域之间的功能连通性处理传入刺激和脑干-脊髓轴其他区域的脊髓。 3）通过3a）测量椎体和脊髓节段相对于桥髓交界处的位置，概述整个人群中人类脊髓节段解剖的多样性； 3b）计算椎体和脊髓节段的相对位置；和3c）预测脊髓节段的位置。结果表明：1）标准的T1和T2加权髓内脊髓信号特征比临床检查无法预测预后。 2）脊髓功能磁共振成像可用于提供创伤性损伤后脊髓可塑性的证据，并且3）脊椎和脊髓节段相对于桥髓交界处的位置自然存在差异，应进行高级成像研究。总体而言，本文介绍的新知识有助于研究人类脊髓的成像技术的发展。

著录项

  • 作者

    Cadotte, David W.;

  • 作者单位

    University of Toronto (Canada).;

  • 授予单位 University of Toronto (Canada).;
  • 学科 Health Sciences Radiology.;Biology Neuroscience.;Health Sciences Medicine and Surgery.
  • 学位 Ph.D.
  • 年度 2014
  • 页码 287 p.
  • 总页数 287
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

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