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Three-dimensional reconstruction of blood vessel lumen from a single x-ray projection image.

机译：从单个X射线投影图像中三维重建血管腔。

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摘要

Stroke and heart attack are the leading causes of death and morbidity in developed countries. The underlying cause is the occlusion of blood vessel lumen by atherosclerotic plaque. Vascular intervention is the dominant method used for treating structural abnormalities in the blood vessels. The success of these minimally invasive procedures depends on accurate determination of lumen and plaque characteristics (e.g., length of diseased vessel segment, percentage luminal narrowing). Clinicians often obtain this information qualitatively from projection images of the blood vessels (angiograms). To provide more quantitative information, other investigators have generated 3D lumen and plaque distributions from two or more views. In this work, we present a novel method for three-dimensional (3D) reconstruction of blood vessel lumens deformed by atherosclerotic plaque from a single x-ray projection image.;This 3D-from-a-single-view technique has several key components. We have developed a novel method to estimate the constant of proportionality relating x-ray path lengths inside the contrast-filled vessel lumen and the pixel values of the x-ray projection image. We used a model-based technique to estimate lumen (pixel value) profiles prior to and after plaque formation, and thereby extract quantitative information regarding the plaque distribution in the vessel. The proportionality constant is then used together with the profile data to generate lumen cross sections. To generate a 3D centerline from a single view, we take advantage of the change in x-ray path length with angle. The angle between vessel medial axis and imaging plane is thereby computed along the indicated segment, and a 3D centerline is constructed. The generated cross sections are positioned on the centerline, and a 3D model is formed.;Intravascular ultrasound (IVUS) imaging is the gold-standard for determination of vessel lumen and plaque size. We have developed a method for generation of 3D vessel lumen from IVUS image sequences based on lumen boundaries indicated in the IVUS images. Our method incorporates techniques to correct for various discrepancies present in the original 3D lumen. The 3D models reconstructed from single-view angiograms compared very well with 3D models reconstructed from IVUS image sequences.;Using this approach, interventionalists will have quantitative 3D plaque distributions for their decision process. These data will also be useful for treatment assessment and patient follow-up. Since the 3D model can be reconstructed from a single image acquired from any view, the required image acquisition/processing time and radiation dose are significantly reduced compared to other techniques that utilize x-rays.
机译：在发达国家，中风和心脏病发作是死亡和发病的主要原因。根本原因是动脉粥样硬化斑块阻塞了血管腔。血管干预是用于治疗血管结构异常的主要方法。这些微创手术的成功取决于对管腔和噬斑特征的准确测定（例如，病变血管段的长度，管腔变窄的百分比）。临床医生通常从血管的投影图像（血管造影）定性地获得此信息。为了提供更多的定量信息，其他研究人员已经从两个或多个视图生成了3D流明和斑块分布。在这项工作中，我们提出了一种从单个X射线投影图像重建因动脉粥样硬化斑块而变形的血管腔的三维（3D）的新方法。这种3D单视角技术具有几个关键要素。我们已经开发出一种新颖的方法来估计与造影剂填充的血管腔内的x射线路径长度和x射线投影图像的像素值相关的比例常数。我们使用基于模型的技术来估计斑块形成之前和之后的管腔（像素值）轮廓，从而提取关于血管中斑块分布的定量信息。然后将比例常数与轮廓数据一起使用以生成内腔横截面。为了从单个视图生成3D中心线，我们利用了x射线路径长度随角度的变化。因此，沿着指示的线段计算血管内侧轴与成像平面之间的角度，并构建3D中心线。生成的横截面位于中心线上，并形成3D模型。血管内超声（IVUS）成像是确定血管内腔和斑块大小的金标准。我们已经开发了一种基于IVUS图像中指示的管腔边界从IVUS图像序列生成3D血管腔的方法。我们的方法采用了多种技术来校正原始3D流明中存在的各种差异。从单视图血管造影照片重建的3D模型与从IVUS图像序列重建的3D模型相比非常好。使用这种方法，介入医师的决策过程将具有定量的3D斑块分布。这些数据对于治疗评估和患者随访也将是有用的。由于可以从任何视图获取的单个图像中重建3D模型，因此与使用X射线的其他技术相比，所需的图像获取/处理时间和辐射剂量大大减少。

著录项

  • 作者

    Erdemir, Erhan.;

  • 作者单位

    State University of New York at Buffalo.;

  • 授予单位 State University of New York at Buffalo.;
  • 学科 Health Sciences Radiology.;Physics Radiation.;Computer Science.
  • 学位 Ph.D.
  • 年度 2010
  • 页码 178 p.
  • 总页数 178
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

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