Determining the Optimal Stockpile Level for Combination Vaccines

机译：确定组合疫苗的最佳库存水平

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By 2015, vaccine shortages still remained one of the major problems around the globe, as described in the annual secretariat report of the Global Vaccine Action Plan (GVAP). Despite multiple initiatives to reduce vaccine shortages, supply interruptions are unexpected and unavoidable. To mitigate the risk of such interruptions, vaccine stockpiles have traditionally been the tool of choice. However, the models used to determine vaccine stockpile levels have only considered the use of monovalent vaccines, which provide protection against a single disease. This study aims to determine optimal stockpile levels for combination vaccines, which provide protection against multiple diseases. First, through discrete event simulation, we explore the effect on antigen shortages while maintaining stockpiles of multiple vaccines from multiple suppliers with different reliability conditions. We consider policies that mimic those of a decision maker that can either use vaccines with the most or the least reliable supply to set up the safety stockpile. Second, we propose a stochastic tractable safety stock model that considers the availability of a pool of monovalent and combination vaccines in the stockpile. Finally, we contrast the recommendations from the simulation with those from the stochastic safety stock model, and we analyze the effect of having a mix of combination and monovalent vaccines to mitigate the shortage risks for any given antigen.

机译：如《全球疫苗行动计划》（GVAP）年度秘书处报告所述，到2015年，疫苗短缺仍然是全球主要问题之一。尽管采取了减少疫苗短缺的多项举措，但供应中断是出乎意料且不可避免的。为了减轻这种中断的风险，传统上一直选择疫苗库存。但是，用于确定疫苗储备水平的模型仅考虑了单价疫苗的使用，该单价疫苗可预防单一疾病。这项研究旨在确定组合疫苗的最佳储备水平，该组合疫苗可预防多种疾病。首先，通过离散事件模拟，我们探索了对抗原短缺的影响，同时保持了来自多家具有不同可靠性条件的供应商的多种疫苗的库存。我们考虑的政策模仿决策者的政策，他们可以使用供应量最大或最不可靠的疫苗来建立安全库存。其次，我们提出了一种随机易处理的安全库存模型，该模型考虑了库存中一价和组合疫苗池的可用性。最后，我们将模拟中的建议与随机安全库存模型中的建议进行对比，并分析混合使用混合疫苗和单价疫苗对减轻任何给定抗原短缺风险的影响。

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作者
Aher, Sheetal.;
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Rochester Institute of Technology.;

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授予单位 Rochester Institute of Technology.;
学科 Industrial engineering.;Public health.;Epidemiology.
学位 M.S.
年度 2017
页码 42 p.
总页数 42
原文格式 PDF
正文语种 eng
中图分类公共建筑;
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1. Framework for Optimal Global Vaccine Stockpile Design for Vaccine-Preventable Diseases: Application to Measles and Cholera Vaccines as Contrasting Examples [J] . Thompson Kimberly M., Tebbens Radboud J. Duintjer Risk analysis . 2016,第7期

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2. A MULTI-ATTRIBUTE APPROACH FOR SETTING PEDIATRIC VACCINE STOCKPILE LEVELS [J] . Ruben A. Proano, Sheldon H. Jacobson, Janet A. Jokela Journal of industrial and management optimization . 2010,第4期

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4. A Stochastic Approach to Determine the Optimal Vaccine Vial Size [C] . Aswin Dhamodharan, Ruben A. Proano, Seshavadhani Kumar Annual Conference and Expo of the Institute of Industrial Engineers . 2014

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5. Use of chance-constrained programming techniques to determine optimal insurance deductible levels. [D] . Shlaes, Carole. 1995

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6. Utility of serum squamous cell carcinoma antigen levels at the time of recurrent cervical cancer diagnosis in determining the optimal treatment choice [O] . Kotaro Shimura, Seiji Mabuchi, Takeshi Yokoi, 2013

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7. ABSTRACTudThe purpose of this research is to obtain an optimal formulations of Black mulberry leaves dried noodle product by using Design Expert Application with Design Mixture D-optimal method.udThis research was done with two phases. The preliminary procedures research is to determine levels of antioxidant activity, chlorophyll content, and the levels of tannin that was contained in black mulberry leaves, the black mulberry leaf flour, a pare fruits, and pare flour. Primary research is to determine the best formulation by using a Mixture Design Expert Design D-optimal method, for a purpose is to optimized the Black mulberry leaf dry noodle. Responses in this studies are a chemical analysis response by using a crude fiber analysis and protein analysis. Physical response is water absorption. Sensory response are color, flavor, and odor.udBlack mulberry leaves dried noodles was made from wheat flour, black mulberry leaf flour, and pare flour, other materials such as an eggs, water, salt, and sodium bicarbonate, of the 16 formulations that has offered to produce an optimal formulation based on desirability which contains 39.69 Flour,14.25 Black Mulberry Leaves flour, 3.06 Pare fruit and flour amounted, and other materials are 30 water, 10 eggs, 2 salt, and 1 sodium bicarbonate. The formulation has been result by program 11,05 crude fiber content, 12.93 protein, 274.31 water absorption, 4,31 for color attribute, 3,87 for taste attribute, and 3,71 for aroma attribute.ududKeyword: Black mulberry leaf dried noodles, optimization. [O] . Leti Nurlatifah Alumni, Yudi Garnida DS, Tantan Widiantara DS 2017

机译：抽象 ud本研究的目的是通过使用带有Design Mixture D-最优方法的Design Expert Application获得黑桑叶干面条产品的最佳配方。 ud这项研究分两个阶段进行。初步程序研究是确定抗氧化剂活性，叶绿素含量以及黑桑叶，黑桑叶粉，果皮和果皮中所含单宁的含量。首要研究是通过使用Mixture Design Expert Design D-optimal方法确定最佳配方，目的是优化黑桑叶干面条。本研究中的反应是通过使用粗纤维分析和蛋白质分析进行的化学分析反应。物理反应是吸水。感官反应是颜色，味道和气味。黑桑叶干面条由小麦粉，黑桑叶粉和削皮粉，鸡蛋，水，盐和碳酸氢钠等其他材料制成，这16种配方可根据需要提供最佳配方其中包含39.69％的面粉，14.25％的黑桑叶面粉，3.06％的去皮水果和面粉，其他材料是30％的水，10％的鸡蛋，2％的盐和1％的碳酸氢钠。该配方是通过程序11,05％的粗纤维含量，12.93％的蛋白质，274.31％的吸水率，4.31的颜色属性，3,87的味道属性和3,71的芳香属性得出的。 ud关键字：黑桑叶干面条，优化。

Determining the Optimal Stockpile Level for Combination Vaccines

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