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首页> 外文学位 >Validation of conformal radiotherapy treatments in 3D using polymer gel dosimeters and optical computed tomography.
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Validation of conformal radiotherapy treatments in 3D using polymer gel dosimeters and optical computed tomography.

机译：使用聚合物凝胶剂量计和光学计算机断层扫描在3D模式下验证保形放射治疗。

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摘要

Polymer gel dosimeters are a three dimensional (3D) dosimetry system that may be conveniently applied for verifying highly conformal radiation therapies where standard dosimetry techniques are insufficient. Polymer gel dosimetry with optical computed tomography (OptCT) can be used to measure spatial dose distributions with high resolution. While long experience with MRI has yielded many studies reporting on experiments involving validation of clinical deliveries using polymer gel dosimeters, there are very few studies of this type where OptCT is used. OptCT is a relatively new technique and consequently has not yet been adopted into the clinical environment. As a result, methods and software tools for integrating OptCT measurements into clinical systems are not available. Previous studies from the Medical Physics research group at the Cancer Centre of Southeastern Ontario (CCSEO) and Queen's University have therefore been limited to simple deliveries and two dimensional (2D) comparisons. In this thesis various software tools and calibration techniques have been developed to allow comparative analysis between OptCT measurements with dose distributions calculated by treatment planning software. Further, a modification of the gamma-evaluation (Low et al. 1998) is presented whereby the vector components of gamma are used to identify the sources of disagreement between compared dose distributions. Test simulations of the new gamma-tool revealed that individual vector components of gamma, as well as the resulting vector field can be used to identify certain types of disagreements between dose distributions: especially spatial misalignments caused by geometric misses. The polymer gel dosimetry tools and analysis software were applied to a clinical validation mimicking a prostate conformal treatment with patient setup correction using image guidance. In one experiment greater than 90% agreement was found between dose distributions in 4%T 50%C NIPAM/Bis dosimeters (Senden et al. 2006) measured with the Vista OptCT unit and dose distributions calculated by Eclipse treatment planning software.
机译：聚合物凝胶剂量计是一种三维（3D）剂量测定系统，可以方便地应用于验证标准剂量测定技术不足的高度保形放射疗法。带有光学计算机断层扫描（OptCT）的聚合物凝胶剂量测定法可用于高分辨率测量空间剂量分布。尽管MRI的长期经验已产生许多研究报告，其中涉及使用聚合物凝胶剂量计验证临床分娩的实验，但很少有使用OptCT的此类研究。 OptCT是一种相对较新的技术，因此尚未被临床环境采用。结果，没有将OptCT测量结果集成到临床系统中的方法和软件工具。因此，来自安大略省东南部癌症中心（CCSEO）和皇后大学的医学物理研究小组的先前研究仅限于简单分娩和二维（2D）比较。在本文中，已经开发了各种软件工具和校准技术，以允许在OptCT测量与通过治疗计划软件计算的剂量分布之间进行比较分析。此外，提出了对伽马评估的一种修改（Low等人，1998年），其中伽马的向量成分用于识别比较剂量分布之间分歧的根源。新的伽玛工具的测试模拟表明，伽玛的各个矢量分量以及所得的矢量场可用于识别剂量分布之间的某些类型的分歧：特别是由几何错位引起的空间未对准。聚合物凝胶剂量测定工具和分析软件已应用于临床验证，该临床验证模仿了采用图像指导的患者设置校正的前列腺保形治疗。在一项实验中，发现使用Vista OptCT装置测量的4％T 50％C NIPAM / Bis剂量计（Senden等人，2006年）的剂量分布与通过Eclipse治疗计划软件计算的剂量分布之间的一致性超过90％。

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  • 作者

    Holmes, Oliver Edwin.;

  • 作者单位

    Queen's University (Canada).;

  • 授予单位 Queen's University (Canada).;
  • 学科 Physics Radiation.
  • 学位 M.Sc.
  • 年度 2009
  • 页码 144 p.
  • 总页数 144
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

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